Irritable Bowel Syndrome May Be Associated with Maternal Inheritance and Mitochondrial DNA Control Region Sequence Variants

• Published in: Digestive diseases and sciences Vol. 59; no. 7; pp. 1392 - 1397
• Main Authors: van Tilburg, Miranda A. L., Zaki, Essam A., Venkatesan, Thangam, Boles, Richard G.
• Format: Journal Article
• Language: English
• Published: Boston Springer US 01.07.2014; Springer; Springer Nature B.V
• Subjects: Adult; Biochemistry; Case-Control Studies; Chronic fatigue syndrome; DNA, Mitochondrial; Female; Gastroenterology; Genetic aspects; Genetic polymorphisms; Genetic research; Hepatology; Humans; Irritable bowel syndrome; Irritable Bowel Syndrome - genetics; Male; Medicine; Medicine & Public Health; Middle Aged; Migraine; Mitochondrial DNA; Oncology; Original Article; Pedigree; Pilot Projects; Polymorphism, Genetic; Sequence Analysis, DNA; Transplant Surgery; Genetics; Cellular energy metabolism; Functional gastrointestinal disorders; Co-morbidity
• ISSN: 0163-2116; 1573-2568
• DOI: 10.1007/s10620-014-3045-2

Background and Aim Mitochondrial dysfunction has been implicated in various functional disorders that are co-morbid to irritable bowel syndrome (IBS) such as migraine, depression and chronic fatigue syndrome. The aim of the current case–control pilot study was to determine if functional symptoms in IBS show a maternal inheritance bias, and if the degree of this maternal inheritance is related to mitochondrial DNA (mtDNA) polymorphisms. Methods Pedigrees were obtained from 308 adult IBS patients, 102 healthy controls, and 36 controls with inflammatory bowel disease (IBD), all from Caucasian heritage, to determine probable maternal inheritance. Two mtDNA polymorphisms (16519T and 3010A), which have previously been implicated in other functional disorders, were assayed in mtDNA haplogroup H IBS subjects and compared to genetic data from 344 published haplogroup H controls. Results Probable maternal inheritance was found in 17.5 % IBS, 2 % healthy controls and 0 % IBD controls ( p  < .0001). No difference was found between IBS and control for 3010A, and a trend was found for 16519T ( p  = 0.05). IBS with maternal inheritance were significantly more likely to have the 16519T than controls (OR 5.8; 95 % CI 1.5–23.1) or IBS without maternal inheritance (OR 5.2; 95 % CI 1.2–22.6). Conclusions This small pilot study shows that a significant minority (1/6) of IBS patients have pedigrees suggestive of maternal inheritance. The mtDNA polymorphism 16519T, which has been previously implicated in other functional disorders, is also associated with IBS patients who display maternal inheritance. These findings suggest that mtDNA-related mitochondrial dysfunction may constitute a sub-group within IBS. Future replication studies in larger samples are needed.