Prevalent coinfection and associated factors for Hepatitis B, Hepatitis C, and Human Immunodeficiency Virus in patients submitted to renal replacement therapy: A cross-sectional study of 21 dialysis units in the State of Mexico

• Published in: PloS one Vol. 17; no. 12; p. e0275238
• Main Authors: Palomo-Piñón, Silvia, Antonio-Villa, Neftali Eduardo, García-Cortés, Luis Rey, Rojano-Mejía, David, González-Palomo, Paula, Martínez-Olivares, Marilin Victoria, Santillán-Arreygué, Leopoldo, Bertadillo-Mendoza, Olga Margarita, Mejia-Rodriguez, Oliva, Ontiveros, Abraham Santos, de Los Angeles Dichi-Romero, Maria, Herrera-Morales, Blanca Estela, Serafín-Méndez, Berenice, Nava-Ayala, Flor Araceli, Torres-Valle, Delfino, Medrano-Lopez, Francisco, Aguinao-Velazquez, Tabata Gabriela, de Los Santos, Antonio Aguilar, Cruz, Alfonso Hernandez, Cruz-Arce, Maria Adriana, Espinosa, Marcos Sebastian Pineda, Mejia-Dominguez, Laura
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 01.12.2022; Public Library of Science (PLoS)
• Subjects: Biology and life sciences; Care and treatment; Chronic kidney failure; Coinfection - epidemiology; Comorbidity; Complications and side effects; Cross-Sectional Studies; Demographic aspects; Female; Hepacivirus; Hepatitis B; Hepatitis B - complications; Hepatitis B - epidemiology; Hepatitis C; Hepatitis C - complications; Hepatitis C - epidemiology; HIV; HIV infection; HIV Infections - complications; HIV Infections - epidemiology; Humans; Male; Medicine and Health Sciences; Mexico - epidemiology; Middle Aged; People and places; Renal Dialysis; Renal Replacement Therapy; Risk factors; Mexico
• ISSN: 1932-6203; 1932-6203
• DOI: 10.1371/journal.pone.0275238

Chronic kidney disease (CKD) predispose to viral coinfections in patients submitted to renal replacement therapy (RRT); nevertheless, few reports have been performed to elucidate the current epidemiology within this population in Mexico. To estimate the prevalence of HBV, HCV, and HIV coinfection and to explore factors associated with prevalent coinfection in patients living with renal failure undergoing to RRT. A multicenter cross-sectional recruitment across 21 units at the Mexican Institute of Social Security (IMSS) at the State of Mexico was performed during 2019. A standardized clinical questionnaire was performed to elucidate individual and relatives-related conditions. A treatment facility questionnaire was applied to the chief responsible of each unit to explore treatment facility variables. Serological testing, clinical, biochemical, and anthropometrical parameters were extracted from clinical records. In 1,304 patients (57.5% male, mean age 45.5 (SD: 15.6) years, and 95.8% in hemodialysis), the prevalence of any viral coinfection was 3.14% (95% CI: 2.32%-4.23%). The highest viral coinfection prevalence were for HCV, HBV, and HIV, in which men and subjects diagnosed after 2010's had the highest rates. We identify that being submitted to peritoneal dialysis, being treated in a surrogated dialysis center and living with a close relative with prior hepatitis coinfection were associated factors for any viral coinfection. In patients submitted to RRT, the prevalence of viral coinfection remains high compared with general population. Screening strategies, medical awareness and targeted public healthcare policies should prioritize better care practices within patients submitted to RRT in Mexico.