SARS-CoV-2-related mortality decrease in nursing home residents given multiple COVID-19 boosters

• Published in: The Lancet infectious diseases Vol. 23; no. 10; pp. e393 - e394
• Main Authors: Blom, Kim, Fjällström, Peter, Molnár, Christian, Åberg, Mikael, Vikström, Linnea, Wigren-Byström, Julia, Bennet, Louise, Widerström, Micael, Rasmussen, Gunlög, Klingström, Jonas, Forsell, Mattias N E, Johansson, Anders F
• Format: Journal Article
• Language: English
• Published: London Elsevier Ltd 01.10.2023; Elsevier Limited
• Subjects: Antibodies; Antibody response; COVID-19; COVID-19 vaccines; Folkhälsovetenskap, global hälsa, socialmedicin och epidemiologi; Health Sciences; Hälsovetenskap; Immunoglobulin G; Infectious diseases; Medical and Health Sciences; Medicin och hälsovetenskap; Mortality; mRNA; Nursing homes; Public health; Public Health, Global Health, Social Medicine and Epidemiology; Severe acute respiratory syndrome coronavirus 2; Vaccines
• ISSN: 1473-3099; 1474-4457; 1474-4457
• DOI: 10.1016/S1473-3099(23)00548-0

Two doses of COVID-19 mRNA vaccines in the primary series and a booster dose induce a strong antibody response, however, this response can be weak in people older than 80 years.1,2 For adults aged more than 80 years, the Public Health Agency of Sweden has endorsed booster doses every 6 months.3 We have tracked the antibody concentrations in residents of 115 nursing homes every three months with care staff assisted self-collected quantitative microsampling of blood and collected national register data on age, sex, and mortality date linked to individual nursing home residents (appendix pp 2–3). No significant difference between individuals with the 20% lowest and those with higher spike-specific IgG antibodies was observed (figure D, appendix p 4). [...]vaccine doses four, five, and six correlated with decreased COVID-19 mortality among nursing home residents, including those with lower vaccine-induced antibody responses.