Spices and culinary herbs for the prevention and treatment of breast cancer: A comprehensive review with mechanistic insights

• Published in: Cancer pathogenesis and therapy Vol. 3; no. 3; pp. 197 - 214
• Main Authors: Ali, Md. Liakot, Noushin, Fabiha, Sadia, Qurratul Ain, Metu, Afroz Fathema, Meem, Jannatul Naima, Chowdhury, Md. Tanvir, Rasel, Md. Hossain, Suma, Khurshida Jahan, Alim, Md. Abdul, Jalil, Muhammad Abdul, Mamun, Md. Jahirul Islam, Hasan, Md. Mahmudul, Hoque, Neamul, Azme, Eva
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 01.05.2025; Elsevier
• Subjects: Antineoplastic agents; Breast cancer; Complementary therapies; Phytochemicals; Review; Spice; Complementary therapies; Spice; Breast cancer; Phytochemicals; Antineoplastic agents
• ISSN: 2949-7132; 2097-2563; 2949-7132
• DOI: 10.1016/j.cpt.2024.07.003

Breast cancer (BC) continues to be the primary malignant neoplasm affecting women. For many years, traditional approaches such as chemotherapy, hormone therapy, radiation, and surgical interventions have been employed to treat BC. However, these therapies often fall short due to considerable adverse effects and the development of multidrug resistance or tolerance. Spices and culinary herbs that have been utilized in culinary practices for millennia have also demonstrated therapeutic effects in traditional medicinal practices serving to both prevent and treat BC. This review aims to comprehensively explore the roles and underlying mechanisms through which spices and culinary herbs exert anti-BC properties. These natural ingredients exhibit diverse anti-BC effects that encompass diverse mechanisms, including the inhibition of BC cell proliferation, migration, metastasis, and angiogenesis, as well as the induction of cell cycle arrest and apoptosis. These actions are achieved by targeting signaling pathways such as phosphoinositide 3-kinase (PI3K)/protein kinase B (Akt)/mammalian target of rapamycin (mTOR), notch signaling, Hedgehog signaling, nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB), and Wingless/int (Wnt)/β-catenin signaling pathways that are predominantly overexpressed in breast tumors or are exploited by them to promote cancer progression. Additionally, compounds such as curcumin, allicin, gingerol, zerumbone, diosgenin, capsaicin, piperine, quercetin, malabaricone C, eugenol, cardamomin, carnosol, cinnamaldehyde, sinigrin present in these spices and herbs may be more effective with reduced side effects against BC compared to conventional chemotherapeutic drugs. This review presents a concise overview of the potential contributions of spices, culinary herbs, and their potent bioactive constituents against BC, with particular emphasis on elucidating their mechanisms of action. [Display omitted] •Breast cancer is the most prevalent cancer among women globally•Spices and culinary herbs demonstrate strong pharmacological activities against various diseases•Spices and culinary herbs exhibit preventive and therapeutic effects against breast cancer•Spices and culinary herbs are safe and effective and may serve as valuable additions in the treatment of breast cancer