Impairment of the internal forward model and feedback mechanisms for vocal sensorimotor control in post-stroke aphasia: evidence from directional responses to altered auditory feedback

• Published in: Experimental brain research Vol. 242; no. 1; pp. 225 - 239
• Main Authors: Khoshhal Mollasaraei, Zeinab, Behroozmand, Roozbeh
• Format: Journal Article
• Language: English
• Published: Berlin/Heidelberg Springer Berlin Heidelberg 01.01.2024; Springer; Springer Nature B.V
• Subjects: Aphasia; Aphasia - etiology; Auditory stimuli; Biomedical and Life Sciences; Biomedicine; brain; Brain injury; Care and treatment; Complications and side effects; Diagnosis; Feedback; Feedback, Sensory - physiology; Frequency; Hearing; Hemispheric laterality; Humans; Motor task performance; Neurology; Neurosciences; Pitch Perception - physiology; Research Article; Risk factors; Sensorimotor system; Speech; Speech - physiology; Stroke; Stroke (Disease); Voice - physiology; United States; Aphasia; Sensorimotor integration; Stroke; Vocal motor control; Auditory feedback; Internal forward model
• ISSN: 0014-4819; 1432-1106; 1432-1106
• DOI: 10.1007/s00221-023-06743-1

The present study examined opposing and following vocal responses to altered auditory feedback (AAF) to determine how damage to left-hemisphere brain networks impairs the internal forward model and feedback mechanisms in post-stroke aphasia. Forty-nine subjects with aphasia and sixty age-matched controls performed speech vowel production tasks while their auditory feedback was altered using randomized ± 100 cents upward and downward pitch-shift stimuli. Data analysis revealed that when vocal responses were averaged across all trials (i.e., opposing and following), the overall magnitude of vocal compensation was significantly reduced in the aphasia group compared with controls. In addition, when vocal responses were analyzed separately for opposing and following trials, subjects in the aphasia group showed a significantly lower percentage of opposing and higher percentage of following vocal response trials compared with controls, particularly for the upward pitch-shift stimuli. However, there was no significant difference in the magnitude of opposing and following vocal responses between the two groups. These findings further support previous evidence on the impairment of vocal sensorimotor control in aphasia and provide new insights into the distinctive impact of left-hemisphere stroke on the internal forward model and feedback mechanisms. In this context, we propose that the lower percentage of opposing responses in aphasia may be accounted for by deficits in feedback-dependent mechanisms of audio-vocal integration and motor control. In addition, the higher percentage of following responses may reflect aberrantly increased reliance of the speech system on the internal forward model for generating sensory predictions during vocal error detection and motor control.