Continuous veno-venous hemofiltration yields better renal outcomes than intermittent hemodialysis among traumatic intracranial hemorrhage patients with acute kidney injury: A nationwide population-based retrospective study in Taiwan

• Published in: PloS one Vol. 13; no. 9; p. e0203088
• Main Authors: Tseng, Min-Feng, Chou, Chu-Lin, Chung, Chi-Hsiang, Chien, Wu-Chien, Chen, Ying-Kai, Yang, Hsiu-Chien, Liao, Chen-Yi, Wei, Kuang-Yu, Wu, Chia-Chao
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 20.09.2018; Public Library of Science (PLoS)
• Subjects: Acute kidney failure; Acute Kidney Injury - complications; Acute Kidney Injury - epidemiology; Acute Kidney Injury - therapy; Adult; Biology and Life Sciences; Brain hemorrhage; Care and treatment; Comparative analysis; Diabetes Complications - epidemiology; Female; Follow-Up Studies; Health aspects; Hemodialysis; Hemofiltration; Humans; Intracranial Hemorrhage, Traumatic - complications; Intracranial Hemorrhage, Traumatic - epidemiology; Intracranial Hemorrhage, Traumatic - therapy; Male; Medicine and Health Sciences; Patient outcomes; Renal Dialysis; Renal replacement therapy; Research and Analysis Methods; Retrospective Studies; Risk Factors; Taiwan; Taiwan
• ISSN: 1932-6203; 1932-6203
• DOI: 10.1371/journal.pone.0203088

Traumatic intracranial hemorrhage (TICH) patients with acute kidney injury (AKI) were reported to have a high mortality rate. Renal replacement therapy (RRT) is indicated for patients with a severe kidney injury. This study aimed to compare the effects of different RRT modalities regarding chronic dialysis rate among adult TICH patients with AKI. A retrospective search of computerized hospital records from 2000 to 2010 for patients with a discharge diagnosis of TICH was conducted to identify the index cases. We collected the data of TICH patients with increased intracranial pressure combined with severe AKI who received intermittent hemodialysis (IHD) or continuous veno-venous hemofiltration (CVVH) as RRT. The outcome was dialysis dependence between 2000 and 2010. From a total of 310 patients who were enrolled in the study, 134 (43%) received CVVH and 176 (57%) received IHD. The risk of dialysis dependency was significantly lower in the CVVH group than in the IHD group (adjusted hazard ratio: 0.368, 95% CI, 0.158-0.858, P = 0.034). Diabetes mellitus and coronary artery disease were risk factors for dialysis dependency. CVVH compared with IHD modality was associated with lower dialysis dependency rate in TICH patients combined with AKI and diabetes mellitus and those with an injury severity score (ISS) ≥16. CVVH may yield better renal outcomes than IHD among TICH patients with AKI, especially those with diabetes mellitus and an ISS ≥16. The beneficial impact of CVVH on TICH patients needs to be clarified in a large cohort study in future.