Personalized endoprostheses for the proximal humerus and scapulohumeral joint in dogs: Biomechanical study of the muscles' contributions during locomotion

• Published in: PloS one Vol. 17; no. 1; p. e0262863
• Main Authors: Le Bras, Linh-Aurore, Timercan, Anatolie, Llido, Marie, Petit, Yvan, Seguin, Bernard, Lussier, Bertrand, Brailovski, Vladimir
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 24.01.2022; Public Library of Science (PLoS)
• Subjects: Animals; Artificial limbs; Biology and Life Sciences; Biomechanical Phenomena; Bone Neoplasms - physiopathology; Bone Neoplasms - surgery; Care and treatment; Design and construction; Dog Diseases - physiopathology; Dog Diseases - surgery; Dogs; Engineering and Technology; Health aspects; Humerus; Humerus - physiopathology; Humerus - surgery; Locomotion; Male; Mechanical properties; Medicine and Health Sciences; Muscle, Skeletal - physiopathology; Muscle, Skeletal - surgery; Osteosarcoma; Osteosarcoma - physiopathology; Osteosarcoma - surgery; Physiological aspects; Prostheses and Implants; Prosthesis Design; Scapula - physiopathology; Scapula - surgery; Shoulder joint; Shoulder Joint - physiopathology; Shoulder Joint - surgery; Canada
• ISSN: 1932-6203; 1932-6203
• DOI: 10.1371/journal.pone.0262863

Osteosarcoma represents one of the most common bone tumours in dogs. It commonly occurs in the proximal humerus, the most affected anatomic site. Until recently, amputation or limb-sparing surgery leading to an arthrodesis coupled with chemotherapy were the only available treatments, but they often lead to complications, reduced mobility and highly impact dog's quality of life. Prototypes of both articulated and monobloc (no mobility) patient-specific endoprostheses have been designed to spare the limb afflicted with osteosarcoma of the proximal humerus. This study focuses on the biomechanical effects of endoprostheses and shoulder muscle kinematics. For each of the endoprosthesis designs, a minimal number of muscles needed to ensure stability and a certain degree of joint movement during walking is sought. A quasi-static study based on an optimization method, the minimization of the sum of maximal muscle stresses, was carried out to assess the contribution of each muscle to the shoulder function. The identification of the most important muscles and their impact on the kinematics of the prosthetic joint lead to an improvement of the endoprosthesis design relevance and implantation feasibility.