Antibody-Directed Urokinase: A Specific Fibrinolytic Agent

A specific fibrinolytic agent was synthesized by covalently coupling urokinase to a monoclonal antibody that was fibrin-specific and did not cross-react with fibrinogen. The antibody was raised against a synthetic peptide representing the seven amino-terminal residues of the beta chain of human fibr...

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Published inScience (American Association for the Advancement of Science) Vol. 229; no. 4715; pp. 765 - 767
Main Authors Bode, Christoph, Matsueda, Gary R., Hui, Kwan Y., Haber, Edgar
Format Journal Article
LanguageEnglish
Published Washington, DC The American Association for the Advancement of Science 23.08.1985
American Association for the Advancement of Science
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Summary:A specific fibrinolytic agent was synthesized by covalently coupling urokinase to a monoclonal antibody that was fibrin-specific and did not cross-react with fibrinogen. The antibody was raised against a synthetic peptide representing the seven amino-terminal residues of the beta chain of human fibrin. The urokinaseantifibrin conjugate retained the original binding specificity of the antibody and showed 100-fold increased fibrinolysis in vitro when compared to unmodified urokinase. The presence of human fibrinogen at plasma concentration did not influence these properties.
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ISSN:0036-8075
1095-9203
DOI:10.1126/science.4023710