1372-P: Micro and Macro Complications Three-Year Follow-up in LANDMARC—Longitudinal Nationwide Study on Real-World Outcomes of Type 2 Diabetes in India

• Published in: Diabetes (New York, N.Y.) Vol. 72; no. Supplement_1; p. 1
• Main Authors: RAIS, NADEEM, DAS, ASHOK K., JOSHI, SHASHANK R., MITHAL, AMBRISH, KALRA, SANJAY, GOPALAKRISHNAN UNNIKRISHNAN, AMBIKA, THACKER, HEMANT, SETHI, BIPIN, CHOWDHURY, SUBHANKAR, SUGUMARAN, AMARNATH, SATPATHY, ASHWINI, GADEKAR, ARVIND, MENON, SHALINI K., NEOGI, RENUKA, CHODANKAR, DEEPA, TRIVEDI, CHIRAG, KUMAR WANGNOO, SUBHASH, ZARGAR, ABDUL H., PRASANNA KUMAR, K.M.
• Format: Journal Article
• Language: English
• Published: New York American Diabetes Association 20.06.2023
• Subjects: Body weight; Cerebral infarction; Coronary artery; Diabetes; Diabetes mellitus (non-insulin dependent); Diabetic neuropathy; Microvasculature; Myocardial infarction; Overweight; Risk factors
• ISSN: 0012-1797; 1939-327X
• DOI: 10.2337/db23-1372-P

Microvascular and macrovascular complications were evaluated during the 3 years (yrs) of LANDMARC, a prospective observational study (CTRI/2017/05/008452) that included participants with T2D on ≥2 antihyperglycemic medications. Out of 6222 evaluable participants (mean baseline age: 52.1 yrs, T2D duration: 8.6 yrs and A1C: 8.05%), 5273 participants completed the 3-yr follow-up. The mean A1C decreased by 0.68% (p<0.0001) in 3 yrs. Microvascular complications were noted in 18.02% (1121/6222) of participants, while the incidence of macrovascular complications was 3.29% (205/6222). Neuropathy was the most commonly reported complication (baseline: 11.8% and 3-yrs: 14.8%). The 3-yr results indicate slightly higher complications among those who were overweight, but the difference was non-significant (p=0.8380); and significantly higher complications among those with suboptimal glycemic control (p<0.0001) or having CV risk factors (p<0.0001) (Table). The most common macrovascular complication was MI. A total of 37 CV deaths were reported, with majority being sudden deaths (n=24), followed by fatal myocardial infarction (MI, n=10), coronary artery procedure (n=2), and stroke (n=1). These results offer insights into disease progression and suggest the need for controlling risk factors and timely treatment adjustment in participants with T2D.