Staphyloxanthin: a potential target for antivirulence therapy

• Published in: Infection and drug resistance Vol. 12; pp. 2151 - 2160
• Main Authors: Xue, Lijun, Chen, Yang Yizhi, Yan, Zhiyun, Lu, Wei, Wan, Dong, Zhu, Huifeng
• Format: Journal Article
• Language: English
• Published: New Zealand Dove Medical Press Limited 01.07.2019; Taylor & Francis Ltd; Dove; Dove Medical Press
• Subjects: Antibiotics; antiinfective drug; antivirulence therapy; Bacteria; Biofilms; Biosynthesis; Carotenoids; Drug development; Drug resistance; Food poisoning; Gene expression; Gram-positive bacteria; Health aspects; Infection; Infection control; Methicillin; Microbial drug resistance; Multidrug resistance; Novels; Pathogens; Penicillin; Pharmaceuticals; Physiological aspects; Pigments; Poisoning; Proteins; Review; Spectrum analysis; Staphylococcal infections; Staphylococcus aureus; Staphylococcus aureus infections; Staphylococcus infections; staphyloxanthin; Strains (organisms); target; Virulence factors; China; antivirulence therapy; antiinfective drug; staphyloxanthin; target
• ISSN: 1178-6973; 1178-6973
• DOI: 10.2147/idr.s193649

Staphylococcus aureus is an important and common Gram-positive bacteria which causes clinical infections and food-poisoning cases. Therapeutic schedules for treatment of infections are facing a challenge because of the emergence of multidrug resistance strains. It is urgent to find new antiinfective drugs to control S. aureus infection. S. aureus strains are capable of producing the golden carotenoid pigment: staphyloxanthin, which acts as an important virulence factor and a potential target for antivirulence drug design. This review is aimed at presenting an updated overview of this golden carotenoid pigment of S. aureus from the biosynthesis of staphyloxanthin, its function, and the genes involved in pigment production to staphyloxanthin: a novel target for antivirulence therapy.