Impact of MenBvac, an outer membrane vesicle (OMV) vaccine, on the meningococcal carriage

• Published in: Vaccine Vol. 31; no. 40; pp. 4416 - 4420
• Main Authors: Delbos, Valérie, Lemée, Ludovic, Bénichou, Jacques, Berthelot, Gilles, Deghmane, Ala-Eddine, Leroy, Jean-Philippe, Houivet, Estelle, Hong, Eva, Taha, Muhamed-Kheir, Caron, François
• Format: Journal Article
• Language: English
• Published: Kidlington Elsevier Ltd 13.09.2013; Elsevier; Elsevier Limited
• Subjects: Acquisitions & mergers; Adolescent; Allergy and Immunology; Animals; Antibodies, Bacterial; Antibodies, Bacterial - blood; Applied microbiology; Asymptomatic Infections; Bacterial Outer Membrane Proteins; Bacterial Outer Membrane Proteins - immunology; Bacteriology; Biological and medical sciences; Carriage; Child; Child, Preschool; Children; Confidence intervals; France; Fundamental and applied biological sciences. Psychology; Herd immunity; herds; Humans; immunity; Immunology; Infant; Life Sciences; Meningitis; Meningitis, Meningococcal; Meningitis, Meningococcal - immunology; Meningitis, Meningococcal - prevention & control; Meningococcal Vaccines; Meningococcal Vaccines - administration & dosage; Meningococcal Vaccines - immunology; Meningococci; Mice; Microbiology; Miscellaneous; Multivariate analysis; Neisseria meningitidis; Neisseria meningitidis - immunology; Outbreak; Outer membrane vesicle vaccine; serotypes; Software; vaccination; Vaccines; Vaccines, antisera, therapeutical immunoglobulins and monoclonal antibodies (general aspects); Vaccinology; volunteers; Young Adult; France; Europe; Outbreak; Outer membrane vesicle vaccine; Meningococci; Carriage; Neisseriaceae; Bacteria; Micrococcales; Outer membrane vesicle; Neisseria meningitidis; Vaccine
• ISSN: 0264-410X; 1873-2518; 0264-410X
• DOI: 10.1016/j.vaccine.2013.06.080

Highlights • We conducted a meningococcal carriage study among children aged 1–7 years old. • We evaluated the impact of MenBvac, an outer membrane vesicle (OMV) vaccine, on the pharyngeal meningococcal carriage. • MenBvac reduces meningococcal carriage and may hence confer herd immunity. • The novel meningococcal B vaccine that includes an OMV component may have an impact on carriage.