Mu-Opioid Receptor Polymorphism Moderates Sensitivity to Parental Behaviors During Characterization of Personality Traits

• Published in: Neuropsychiatric disease and treatment Vol. 16; pp. 2161 - 2167
• Main Authors: Noto, Keisuke, Suzuki, Akihito, Shirata, Toshinori, Matsumoto, Yoshihiko, Takahashi, Nana, Goto, Kaoru, Otani, Koichi
• Format: Journal Article
• Language: English
• Published: New Zealand Dove Medical Press Limited 01.01.2020; Taylor & Francis Ltd; Dove; Dove Medical Press
• Subjects: Attachment; Behavior; Children; Deoxyribonucleic acid; DNA; Gene polymorphism; gene-environment interaction; Genetic aspects; Genetic polymorphisms; Genotype & phenotype; Maternal behavior; Mental disorders; Narcotics; Opioid receptors (type mu); oprm1; Original Research; Parent-child relations; Parental behavior; Parents & parenting; pbi; Personality; Personality traits; Polymorphism; Regression analysis; tci; Japan; gene–environment interaction; OPRM1; TCI; attachment; personality; PBI
• ISSN: 1176-6328; 1178-2021; 1178-2021
• DOI: 10.2147/ndt.s265774

Attachment research shows that attachment experiences with parents in childhood influence the characterization of personality traits. Meanwhile, it is known that mu-opioid receptor function is involved in human attachment. Furthermore, a few studies suggest that the A118G polymorphism of the mu-opioid receptor gene ( ) is associated with altered mu-opioid receptor function. Thus, we examined if the polymorphism moderates the sensitivity to parental behaviors and thereby contributes to the characterization of personality traits. Participants were 725 healthy Japanese. Parenting practices of their parents were evaluated by the Parental Bonding Instrument (PBI) with the care and protection subscales. Personality was evaluated using the Temperament and Character Inventory (TCI). The A118G polymorphism was detected by a PCR method. Multiple regression analyses revealed significant effects of the interaction between the genotype and maternal protection on scores of the self-directedness and cooperativeness dimensions, while significant main effects of the genotype on scores of the TCI were not found. Further analyses showed that there were significant negative correlations between maternal protection scores and the two dimensional scores in the A/A and A/G genotypes with higher correlation coefficients in the former, but not in the G/G genotype. The present study suggests that the polymorphism contributes to the characterization of personality traits by moderating the sensitivity to parental behaviors, especially maternal protection.