Expression of heat shock protein 70 in oral epithelial dysplasia and oral squamous cell carcinoma: An immunohistochemical study

• Published in: Contemporary clinical dentistry Vol. 10; no. 2; pp. 185 - 190
• Main Authors: Priyanka, K, Majumdar, Sumit, Kotina, Sreekanth, Uppala, Divya, Balla, Hyandavi
• Format: Journal Article
• Language: English
• Published: India Wolters Kluwer India Pvt. Ltd 01.04.2019; Medknow Publications and Media Pvt. Ltd; Medknow Publications & Media Pvt. Ltd; Wolters Kluwer - Medknow; Wolters Kluwer Medknow Publications
• Subjects: Biological markers; Biomarkers; Biopsy; Cancer; Carcinogenesis; Carcinoma; Development and progression; Dysplasia; Heat shock proteins; heat shock proteins 70; Hsp70 protein; Immunohistochemistry; Leukokeratosis; Life sciences; Metastasis; Mucosa; Oral cancer; Oral squamous cell carcinoma; Original; Proteins; Squamous cell carcinoma; Statistical analysis; Studies; tumor node and metastasis staging; United States > US; tumor node and metastasis staging; immunohistochemistry; Heat shock proteins 70; oral cancer
• ISSN: 0976-237X; 0976-2361
• DOI: 10.4103/ccd.ccd_101_18

Introduction: Heat shock proteins are biomarkers regulating the degree of differention and aggressiveness in oral carcinogenesis. The study was carried out to evaluate the expression of HSP 70 in histological grades of epithelial dysplasia and oral squamous cell carcinoma using immunohistochemistry. Methodology: A sample of 40, which included 10 (Normal), 15 (epithelial dysplasia) and 15 (oral squamous cell carcinoma) were selected. The biopsy samples were stained using H and E staining and HSP 70 IHC. Results: There was a statistical significant difference in expression of HSP 70 between normal oral mucosal tissue, leukoplakia and OSCC. Discussion and Conclusion: This study concludes the critical role of HSP70 as an oncogene in the development of oral cancer. HSP70 inhibition is, therefore a promising therapeutic approach for cancer treatment.