Wolbachia strain wAu efficiently blocks arbovirus transmission in Aedes albopictus

The global incidence of arboviral diseases transmitted by Aedes mosquitoes, including dengue, chikungunya, yellow fever, and Zika, has increased dramatically in recent decades. The release of Aedes aegypti carrying the maternally inherited symbiont Wolbachia as an intervention to control arboviruses...

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Published inPLoS neglected tropical diseases Vol. 14; no. 3; p. e0007926
Main Authors Mancini, Maria Vittoria, Herd, Christie S, Ant, Thomas H, Murdochy, Shivan M, Sinkins, Steven P
Format Journal Article
LanguageEnglish
Published United States Public Library of Science 10.03.2020
Public Library of Science (PLoS)
Subjects
Aedes - microbiology
Aedes - virology
Animals
Antibiosis
Arbovirus Infections - prevention & control
Arboviruses
Arboviruses - growth & development
Asian tiger mosquito
Biology and Life Sciences
Control
Disease Transmission, Infectious - prevention & control
Drosophila - microbiology
Female
Genetic aspects
Health aspects
Infection control
Male
Medical research
Medicine and Health Sciences
Mosquito Vectors - microbiology
Mosquito Vectors - virology
Wolbachia
Wolbachia - growth & development
Wolbachia - isolation & purification
United Kingdom
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Summary:The global incidence of arboviral diseases transmitted by Aedes mosquitoes, including dengue, chikungunya, yellow fever, and Zika, has increased dramatically in recent decades. The release of Aedes aegypti carrying the maternally inherited symbiont Wolbachia as an intervention to control arboviruses is being trialled in several countries. However, these efforts are compromised in many endemic regions due to the co-localization of the secondary vector Aedes albopictus, the Asian tiger mosquito. Ae. albopictus has an expanding global distribution following incursions into a number of new territories. To date, only the wMel and wPip strains of Wolbachia have been reported to be transferred into and characterized in this vector. A Wolbachia strain naturally infecting Drosophila simulans, wAu, was selected for transfer into a Malaysian Ae. albopictus line to create a novel triple-strain infection. The newly generated line showed self-compatibility, moderate fitness cost and complete resistance to Zika and dengue infections.
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Current address: Dept. of Veterinary Pathobiology, University of Missouri, Columbia, Missouri, United States of America
The authors have declared that no competing interests exist.
ISSN:1935-2735
1935-2727
1935-2735
DOI:10.1371/journal.pntd.0007926