Alternative splicing of Hepatitis B virus: a novel virus/host interaction altering liver immunity

• Published in: Journal of hepatology Vol. 67; no. 4; pp. 687 - 699
• Main Authors: Duriez, Marion, Mandouri, Yassmina, Lekbaby, Bouchra, Wang, Hualin, Schnuriger, Aurélie, Redelsperger, Francois, Guerrera, Chiara, Lefevre, Marine, Fauveau, Veronique, Ahodantin, James, Quetier, Ivan, Chhuon, Cerina, Gourari, Samir, Boissonas, Alexandre, Gill, Upkar, Kennedy, Patrick, Debzi, Nabil, Sitterlin, Delphine, Maini, Mala K, Kremsdorf, Dina, Soussan, Patrick
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 01.10.2017; Elsevier Science Ltd; Elsevier
• Subjects: Alternate splicing; Alternative splicing; Alternative Splicing - immunology; Animals; Antiviral drugs; CCL2; Chemokine CCL2 - metabolism; Enzyme-linked immunosorbent assay; Fibrosis; Flow cytometry; Gastroenterology and Hepatology; Gene expression; Gene regulation; Genomes; HBSP; HBV; Hepatitis; Hepatitis B; Hepatitis B virus - genetics; Hepatitis B virus - immunology; Hepatitis B virus - pathogenicity; Hepatitis B, Chronic - immunology; Hepatitis B, Chronic - virology; Hepatocytes; Hepatoma; Host-Pathogen Interactions - genetics; Host-Pathogen Interactions - immunology; Humans; Immune Evasion - genetics; Immunity; Immunity (Disease); Immunopathogenesis; Inflammation; Life Sciences; Liver; Liver - immunology; Liver - injuries; Liver - virology; Liver fibrosis; Macrophages; Male; Mass spectroscopy; Mice; Mice, Inbred C57BL; Mice, Transgenic; Monocyte chemoattractant protein 1; Monocytes; Polymerase chain reaction; Post-transcription; Reverse transcription; Ribonucleic acid; RNA; RNA Splicing Factors - metabolism; RNA viruses; RNA, Viral - genetics; RNA, Viral - metabolism; RNA-protein interactions; Splicing factors; Transgenic mice; Viral infections; HBV single spliced pregenomic RNA; ALT; phosphate-buffered saline; dHBV; Lipopolysaccharide; Hepatitis B splicing generated protein; HBV; serine-arginine rich protein; PBS; heterogeneous nuclear ribonucleoprotein protein; hnRNP; IP; HBeAg; HBSP transgenic mouse; HCC; HBsAg; Hepatocarcinoma; SP1RNA; RTqPCR; AS; liver fibrosis; Chronic hepatitis B; Bile Duct ligation; ROS; Alternative splicing; Hepatitis B Virus; Carbon tetrachloride; Wild type HBV circulating particles; BDL; TgHBSP; LPS; CCL 4; Intraperitoneal; macrophages; HBe antigen; reactive oxygen species; HBV pregenomic RNA; CCL2; alternate splicing; wtHBV; WT; SR; knockout; figure; KO; Fig; TgHBV; HBs antigen; Thioacetamide; HBV transgenic mouse; pgRNA; TAA; HBSP; reverse transcription polymerase chain reaction; Alanine aminotransferase; CHB; wild-type; defective HBV circulating particles; Liver fibrosis; Macrophages; Alternate splicing
• ISSN: 0168-8278; 1600-0641
• DOI: 10.1016/j.jhep.2017.05.025

Graphical abstract