Lymphoma-Specific Genetic Aberrations in Microvascular Endothelial Cells in B-Cell Lymphomas

• Published in: The New England journal of medicine Vol. 351; no. 3; pp. 250 - 259
• Main Authors: Streubel, Berthold, Chott, Andreas, Huber, Daniela, Exner, Markus, Jäger, Ulrich, Wagner, Oswald, Schwarzinger, Ilse
• Format: Journal Article
• Language: English
• Published: Boston, MA Massachusetts Medical Society 15.07.2004
• Subjects: Adult; Aged; Angiogenesis; Biological and medical sciences; Bone marrow; Chromosome Aberrations; Chromosomes; Endothelial Cells; Endothelium, Vascular - cytology; Female; General aspects; Hematologic and hematopoietic diseases; Humans; In Situ Hybridization, Fluorescence; Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis; Liver Transplantation - adverse effects; Lymphoma; Lymphoma, B-Cell - genetics; Lymphoproliferative Disorders - etiology; Lymphoproliferative Disorders - genetics; Male; Medical sciences; Microcirculation; Middle Aged; Mutation; Neovascularization, Pathologic - genetics; Tandem Repeat Sequences - genetics; Translocation, Genetic; Tumors; Medicine; Microcirculation; Endothelial cell; Lymphoproliferative syndrome; Genetics; Malignant hemopathy; B-Lymphocyte; Lymphoma
• ISSN: 0028-4793; 1533-4406
• DOI: 10.1056/NEJMoa033153

Using combined immunohistochemical and fluorescence in situ hybridization techniques, these investigators found chromosomal abnormalities typical of B-cell lymphomas not only in the lymphoma cells but also in the microvascular endothelial cells in the lymphoma. These findings link lymphoma cells to angiogenesis within the tumor. Like normal tissues, tumors require an adequate supply of oxygen and metabolites and effective removal of waste products. 1 Although normal cells and tissues rely on physiologic angiogenesis, tumor cells induce their own blood supply from the preexisting vasculature. 2 , 3 In a process that is very similar to physiologic angiogenesis, tumors can elicit the sprouting of new blood vessels from preexisting capillaries. 2 Moreover, some aggressive cancers can mimic the activities of endothelial cells by participating in the formation of fluid-conducting, vascular-like networks. 4 This phenomenon occurs without the participation of endothelial cells and is independent of angiogenesis. The mechanism used by the . . .