The future of organ transplantation: from the laboratory to the clinic
This is a short review of tolerance from the point of view of the clinician. Various examples of tolerance occurring in patients and animal models that relate to the clinical experience are described. It is suggested that there may be different mechanisms by which tolerance is achieved, but from the...
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Published in | Philosophical transactions of the Royal Society of London. Series B. Biological sciences Vol. 356; no. 1409; pp. 767 - 771 |
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Main Author | |
Format | Journal Article |
Language | English |
Published |
England
The Royal Society
29.05.2001
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Subjects | |
Online Access | Get full text |
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Summary: | This is a short review of tolerance from the point of view of the clinician. Various examples of tolerance occurring in patients and animal models that relate to the clinical experience are described. It is suggested that there may be different mechanisms by which tolerance is achieved, but from the patient's point of view operational tolerance is the goal, whereby, after a short induction procedure, the patient will maintain good function in the grafted organ indefinitely without maintenance immunosuppression. It is pointed out that such a goal may be difficult to achieve with any given protocol due to the enormous variation between donors and recipients of organ grafts of tissue matching, innate immune reactivity and susceptibility to disturbance of a tolerant state by infections or allergic reactions. Thus the case is made for prope or almost tolerance in which graft acceptance is maintained by a low, non-toxic dosage of maintenance immunosuppression that may not be required indefinitely. |
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Bibliography: | ark:/67375/V84-TJRMX6V7-D istex:1BA08B66AB285664E3F04A43695F0E196D1917FC Theme Issue 'Immunological tolerance and transplantation' compiled by P. J. Morris and K. J. Wood |
ISSN: | 0962-8436 1471-2970 |
DOI: | 10.1098/rstb.2001.0848 |