Metabolic reprogramming in macrophages and dendritic cells in innate immunity

Activation of macrophages and dendritic cells （DCs） by pro-inflammatory stimuli causes them to undergo a metabolic switch towards glycolysis and away from oxidative phosphorylation （OXPHOS）, similar to the Warburg effect in tumors. However, it is only recently that the mechanisms responsible for thi...

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Bibliographic Details
Published inCell research Vol. 25; no. 7; pp. 771 - 784
Main Authors Kelly, Beth, O'Neill, Luke AJ
Format Journal Article
LanguageEnglish
Published London Nature Publishing Group UK 01.07.2015
Nature Publishing Group
Subjects
631/250/2504/133
631/250/2504/342
631/250/262
631/443/319
Animals
Biomedical and Life Sciences
Biosynthesis
Cell Biology
Dendritic Cells - cytology
Dendritic Cells - immunology
Glycolysis - genetics
HIF-1α
Humans
Hypoxia
Immunity, Innate - genetics
Inflammation - genetics
Inflammation - metabolism
Life Sciences
Macrophages - cytology
Macrophages - immunology
Review
Signal Transduction - genetics
Signal Transduction - immunology
代谢
先天免疫
巨噬细胞
树突状细胞
氧化磷酸化
缺氧诱导因子-1α
重编程
macrophage
dendritic cell
metabolic reprogramming
oxidative phosphorylation
glycolysis
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Summary:Activation of macrophages and dendritic cells （DCs） by pro-inflammatory stimuli causes them to undergo a metabolic switch towards glycolysis and away from oxidative phosphorylation （OXPHOS）, similar to the Warburg effect in tumors. However, it is only recently that the mechanisms responsible for this metabolic reprogramming have been elucidated in more detail. The transcription factor hypoxia-inducible factor-la （HIF-la） plays an important role un- der conditions of both hypoxia and normoxia. The withdrawal of citrate from the tricarboxylic acid （TCA） cycle has been shown to be critical for lipid biosynthesis in both macrophages and DCs. Interference with this process actually abolishes the ability of DCs to activate T cells. Another TCA cycle intermediate, succinate, activates HIF-la and pro- motes inflammatory gene expression. These new insights are providing us with a deeper understanding of the role of metabolic reprogramming in innate immunity.
Bibliography:macrophage; dendritic cell; metabolic reprogramming; glycolysis; oxidative phosphorylation
31-1568
Activation of macrophages and dendritic cells （DCs） by pro-inflammatory stimuli causes them to undergo a metabolic switch towards glycolysis and away from oxidative phosphorylation （OXPHOS）, similar to the Warburg effect in tumors. However, it is only recently that the mechanisms responsible for this metabolic reprogramming have been elucidated in more detail. The transcription factor hypoxia-inducible factor-la （HIF-la） plays an important role un- der conditions of both hypoxia and normoxia. The withdrawal of citrate from the tricarboxylic acid （TCA） cycle has been shown to be critical for lipid biosynthesis in both macrophages and DCs. Interference with this process actually abolishes the ability of DCs to activate T cells. Another TCA cycle intermediate, succinate, activates HIF-la and pro- motes inflammatory gene expression. These new insights are providing us with a deeper understanding of the role of metabolic reprogramming in innate immunity.
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ISSN:1001-0602
1748-7838
DOI:10.1038/cr.2015.68