An atlas of the protein-coding genes in the human, pig, and mouse brain

• Published in: Science (American Association for the Advancement of Science) Vol. 367; no. 6482; p. 1090
• Main Authors: Sjöstedt, Evelina, Zhong, Wen, Fagerberg, Linn, Karlsson, Max, Mitsios, Nicholas, Adori, Csaba, Oksvold, Per, Edfors, Fredrik, Limiszewska, Agnieszka, Hikmet, Feria, Huang, Jinrong, Du, Yutao, Lin, Lin, Dong, Zhanying, Yang, Ling, Liu, Xin, Jiang, Hui, Xu, Xun, Wang, Jian, Yang, Huanming, Bolund, Lars, Mardinoglu, Adil, Zhang, Cheng, von Feilitzen, Kalle, Lindskog, Cecilia, Pontén, Fredrik, Luo, Yonglun, Hökfelt, Tomas, Uhlén, Mathias, Mulder, Jan
• Format: Journal Article
• Language: English
• Published: United States The American Association for the Advancement of Science 06.03.2020
• Subjects: Analogies; Animal models; Animals; Antibodies; Architecture; Astrocytes; Atlases as Topic; Biological evolution; Brain; Brain - physiology; Brain architecture; Brain mapping; Cerebellum; Coding; Data acquisition; Data integration; Datasets as Topic; Diseases; Dissection; Exploration; Female; Gene expression; Gene Expression Regulation; Gene mapping; Genes; Genomics; Humans; Hybridization; Hypothalamic-pituitary-adrenal axis; Hypothalamus; Image resolution; Immune system; Integration; Laboratory Procedures; Male; Mammals; Medicin och hälsovetenskap; Mental disorders; Mice; Mice, Inbred C57BL; Microglia; Muscles; Nerve Tissue Proteins - genetics; Nervous system; Neurobiology; Neurosciences; Neurotransmitter receptors; Neurotransmitters; Oligodendrocytes; Open access; Organ Specificity - genetics; Organs; Peptide mapping; Physiology; Profiles; Proteins; Receptors; Regional analysis; Ribonucleic acid; RNA; Skeletal muscle; Species; Species Specificity; Swine; Tissue analysis; Transcriptome; Transcriptomics

The brain, with its diverse physiology and intricate cellular organization, is the most complex organ of the mammalian body. To expand our basic understanding of the neurobiology of the brain and its diseases, we performed a comprehensive molecular dissection of 10 major brain regions and multiple s...