Transcriptional targets of sirtuins in the coordination of mammalian physiology
Sirtuins (Sirts) compose a family of NAD+ -dependent deacetylases and/or ADP-ribosyltransferases, which have been implicated in aging, metabolism, and tolerance to oxidative stress. Many of the biological processes regulated by Sirts result from the adaptation of complex gene-expression programs to...
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Published in | Current opinion in cell biology Vol. 20; no. 3; pp. 303 - 309 |
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Main Authors | , |
Format | Journal Article |
Language | English |
Published |
England
Elsevier Ltd
01.06.2008
Elsevier |
Subjects | |
Online Access | Get full text |
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Summary: | Sirtuins (Sirts) compose a family of NAD+ -dependent deacetylases and/or ADP-ribosyltransferases, which have been implicated in aging, metabolism, and tolerance to oxidative stress. Many of the biological processes regulated by Sirts result from the adaptation of complex gene-expression programs to the energetic state of the cell, sensed through NAD+ levels. To that respect, Sirts, and particularly the founding member of the family Sirt1, have emerged as important regulators of transcription, which they modulate both positively and negatively by targeting histones and transcriptional complex regulatory proteins. This review will focus on recent advances that have started deciphering how mammalian Sirts regulate transcriptional networks and thereby control physiology. |
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Bibliography: | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 ObjectType-Article-2 ObjectType-Feature-3 ObjectType-Review-1 PMCID: PMC2447870 |
ISSN: | 0955-0674 1879-0410 |
DOI: | 10.1016/j.ceb.2008.03.012 |