TMC-169, a New Antibiotic of the Aspochalasin Group Produced by Aspergillus flavipes

• Published in: Journal of antibiotics Vol. 52; no. 6; pp. 575 - 577
• Main Authors: KOHNO, JUN, NONAKA, NOBUAKI, NISHIO, MAKI, OHNUKI, TETSUO, KAWANO, KIMIO, OKUDA, TORU, KOMATSUBARA, SABURO
• Format: Journal Article
• Language: English
• Published: TOKYO JAPAN ANTIBIOTICS RESEARCH ASSOCIATION 1999; JAPAN ANTIBIOT RES ASSN; Japan Antibiotics Research Association
• Subjects: Anti-Bacterial Agents - biosynthesis; Anti-Bacterial Agents - chemistry; Anti-Bacterial Agents - pharmacology; antibiotics; Antibiotics, microbial producers, chemotherapic agents, antiseptics, disinfecting agents; Antineoplastic agents; Applied microbiology; Aspergillus - metabolism; Aspergillus flavipes; aspochalasin A; aspochalasin G; Biological and medical sciences; Biotechnology & Applied Microbiology; Bridged Bicyclo Compounds, Heterocyclic - chemistry; Bridged Bicyclo Compounds, Heterocyclic - metabolism; Bridged Bicyclo Compounds, Heterocyclic - pharmacology; Cell Death - drug effects; Chemical Phenomena; Chemistry, Physical; Chemotherapic agents; Chromatography, Gel; Chromatography, High Pressure Liquid; Fermentation; Fundamental and applied biological sciences. Psychology; General aspects; Humans; Immunology; Life Sciences & Biomedicine; Magnetic Resonance Spectroscopy; Medical sciences; Microbiology; Molecular Structure; Pharmacology & Pharmacy; Pharmacology. Drug treatments; Science & Technology; Spectrophotometry; TMC-169; Tumor Cells, Cultured; Antineoplastic agent; Human; Aspergillus flavipes; Cytotoxicity; NMR spectrometry; Fermentation; In vitro; Biological activity; Fungi; Antibiotic; Established cell line; Microorganism culture; Fungi Imperfecti; Tumor cell; Physicochemical properties; Thallophyta; Structural analysis
• ISSN: 0021-8820; 1881-1469
• DOI: 10.7164/antibiotics.52.575

In the course of screening for new bioactive compounds, a new antibiotic has been isolated from a fungal strain Aspergillus flavipes TC 1446 and was designated TMC-169. Spectroscopic analyses revealed that TMC-169 was a new analog of the aspochalasin group, represented by aspochalasins A similar to G and phomacin C. This paper briefly describes the taxonomy, isolation, physico-chemical properties, structure elucidation and biological activity of TMC-169.