SYNERAZOL, A NEW ANTIFUNGAL ANTIBIOTIC

• Published in: Journal of antibiotics Vol. 44; no. 4; pp. 382 - 389
• Main Authors: ANDO, OSAMU, SATAKE, HITOMI, NAKAJIMA, MUTSUO, SATO, AKIRA, NAKAMURA, TAKEMICHI, KINOSHITA, TAKESHI, FURUYA, KOUHEI, HANEISHI, TATSUO
• Format: Journal Article
• Language: English
• Published: Tokyo JAPAN ANTIBIOTICS RESEARCH ASSOCIATION 1991; Japan Antibiotics Research Association
• Subjects: Antibiotics (antibacterial agents, antifungal agents); Antibiotics, microbial producers, chemotherapic agents, antiseptics, disinfecting agents; Antifungal Agents - chemistry; Antifungal Agents - isolation & purification; Antifungal Agents - pharmacology; Applied microbiology; Aspergillus fumigatus; Aspergillus fumigatus - metabolism; Biological and medical sciences; Candida albicans; Candida albicans - drug effects; Chemical Phenomena; Chemistry, Physical; Clotrimazole - pharmacology; Drug Synergism; Fermentation; Fundamental and applied biological sciences. Psychology; Magnetic Resonance Spectroscopy; Mass Spectrometry; Microbiology; Molecular Structure; Pyrrolidinones - chemistry; Pyrrolidinones - isolation & purification; Pyrrolidinones - pharmacology; Molecular structure; Taxonomy; Biosynthesis; Fermentation; Fungi; Antibiotic; Antifungal agent; Production; Isolation; Fungi Imperfecti; Aspergillus fumigatus; Physicochemical properties; Thallophyta
• ISSN: 0021-8820; 1881-1469
• DOI: 10.7164/antibiotics.44.382

Synerazol, a new antifungal antibiotic, was isolated from cultured broth of Aspergillus fumigatus SANK 10588. The structure was determined based on NMR and mass spectral evidences. Synerazol was found to be a related substance to pseurotin A. Synerazol was active against Candida albicans and other fungi, and showed marked synergistic activity with azole-type antifungal agents.