Mitogenic and Colony-Stimulating Factor-Inducing Activities of Polysaccharide Fractions from the Fruit Bodies of Dictyophora indusiata FISCH

• Published in: Chemical & pharmaceutical bulletin Vol. 39; no. 6; pp. 1615 - 1616
• Main Authors: HARA, Chihiro, KUMAZAWA, Yoshio, INAGAKI, Kazunari, KANEKO, Masahiro, KIHO, Tadashi, UKAI, Shigeo
• Format: Journal Article
• Language: English
• Published: Tokyo The Pharmaceutical Society of Japan 1991; Maruzen
• Subjects: acetylated (1→3)-α-D-mannan; Animals; Basidiomycota - chemistry; Biological and medical sciences; branched (1→3)-β-D-glucan; Cell Division - drug effects; colony-stimulating factor-inducing activity; Colony-Stimulating Factors - biosynthesis; Dictyophora indusiata; Female; fucomannogalactan; General pharmacology; In Vitro Techniques; Medical sciences; Mice; Mice, Inbred C3H; Mice, Inbred C57BL; Mice, Inbred ICR; mitogenic activity; Mitogens - pharmacology; Pharmacognosy. Homeopathy. Health food; Pharmacology. Drug treatments; polysaccharide; Polysaccharides - chemistry; Polysaccharides - pharmacology; Intraperitoneal administration; Immune response; Fruit; Pharmacognosy; Rodentia; Colony stimulating factor; Biological activity; Medicinal plant; Fungi; Vertebrata; Immunostimulant agent; Mammalia; Mouse; Animal; Plant origin; Mitogen; Polysaccharide; Thallophyta
• ISSN: 0009-2363; 1347-5223
• DOI: 10.1248/cpb.39.1615

Biological effects (mitogenic and colony-stimulating factor (CSF)-inducing activities) of five homogeneous polysaccharides and a conjugated polysaccharide fraction isolated from the fruit bodies of Dictyophora indusiata FISCH. were investigated. Fucomannogalactan (T-3-Ad) and conjugated polysaccharide fraction (T-2-A) exhibited significant mitogenic and CSF-inducing activities. Among two β-(1→6)-branched (1→3)-β-D-glucans (T-4-N and T-5-N), only T-4-N showed both mitogenic and CSF-inducing effects. Partially O-acetylated (1→3)-α-D-mannans (T-2-HN and T-3-M') did not show these effects.