Florbetapir PET, FDG PET, and MRI in Down syndrome individuals with and without Alzheimer's dementia

• Published in: Alzheimer's & dementia Vol. 11; no. 8; pp. 994 - 1004
• Main Authors: Sabbagh, Marwan N, Chen, Kewei, Rogers, Joseph, Fleisher, Adam S, Liebsack, Carolyn, Bandy, Dan, Belden, Christine, Protas, Hillary, Thiyyagura, Pradeep, Liu, Xiaofen, Roontiva, Auttawut, Luo, Ji, Jacobson, Sandra, Malek-Ahmadi, Michael, Powell, Jessica, Reiman, Eric M
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.08.2015
• Subjects: Adult; Alzheimer Disease - complications; Alzheimer's disease; Aniline Compounds - metabolism; Brain - diagnostic imaging; Brain - pathology; Dementia; Down syndrome; Down Syndrome - complications; Down Syndrome - pathology; Emergency Services, Psychiatric; Ethylene Glycols - metabolism; FDG-PET; Female; Florbetapir; Fluorodeoxyglucose F18 - metabolism; Humans; Image Processing, Computer-Assisted; Imaging; Magnetic Resonance Imaging; Male; Middle Aged; Neurology; Neuropsychological Tests; PET; Positron-Emission Tomography; FDG-PET; Florbetapir; Imaging; Down syndrome; Alzheimer's disease; PET; Dementia
• ISSN: 1552-5260; 1552-5279
• DOI: 10.1016/j.jalz.2015.01.006

Abstract Introduction Down syndrome (DS) is associated with amyloid b (Ab) deposition. Methods We characterized imaging measurements of regional fibrillar Ab burden, cerebral metabolic rate for glucose (rCMRgl), gray matter volumes (rGMVs), and age associations in 5 DS with dementia (DS/AD1), 12 DS without dementia (DS/AD2), and 9 normal controls (NCs). Results There were significant group differences in mean standard uptake value ratios (SUVRs) for florbetapir with DS/AD1 having the highest, followed by DS/AD2, followed by NC. For [18F]-fluorodeoxyglucose positron emission tomography, posterior cingulate rCMRgl in DS/AD1 was significantly reduced compared with DS/AD2 and NC. For volumetric magnetic resonance imaging (vMRI), hippocampal volumes were significantly reduced for the DS/AD1 compared with DS/AD2 and NC. Age-related SUVR increases and rCMRgl reductions were greater in DS participants than in NCs. Discussion DS is associated with fibrillar Ab, rCMRgl, and rGMV alterations in the dementia stage and before the presence of clinical decline. This study provides a foundation for the studies needed to inform treatment and prevention in DS.