Computational simulation and preparation of fluorescent magnetic molecularly imprinted silica nanospheres for ciprofloxacin or norfloxacin sensing

• Published in: Journal of separation science Vol. 37; no. 24; pp. 3753 - 3759
• Main Authors: Gao, Bo, He, Xin-Ping, Jiang, Yang, Wei, Jia-Tong, Suo, Hui, Zhao, Chun
• Format: Journal Article
• Language: English
• Published: Weinheim Blackwell Publishing Ltd 01.12.2014; Wiley; Wiley Subscription Services, Inc
• Subjects: Analysis; Antibiotics; Biological and medical sciences; Cadmium; Cadmium Compounds - chemistry; ciprofloxacin; Ciprofloxacin - urine; Computation; detection limit; energy; Ferric Compounds - chemistry; Fluorescence; fluorescence emission spectroscopy; Fluorescent Dyes - chemical synthesis; Fluorescent Dyes - chemistry; Fluoroquinolones; Fourier transform infrared spectroscopy; General pharmacology; Human; Humans; Magnetic Phenomena; Magnetic separation; Medical sciences; Molecular Dynamics Simulation; Molecular Imprinting; Molecular modeling; Molecular Structure; nanoparticles; nanospheres; Nanospheres - chemistry; Norfloxacin; Norfloxacin - urine; Particle Size; Pharmacology. Drug treatments; Polymerization; polymers; Polymers - chemical synthesis; Polymers - chemistry; Quantum Dots; scanning electron microscopy; Separation; Silica; Silicon Dioxide - chemistry; Simulation; Spectrum analysis; Surface Properties; Tellurium - chemistry; Ultraviolet; ultraviolet-visible spectroscopy; Urine; X-ray diffraction; Fluoroquinolones; Biological fluid; Quantum dot; Chemical analysis; Nanoparticle; Fluorescence; Modeling; Fluorescence spectrometry; Surface structure; Affinity adsorbent; Characterization; Fluoroquinolone derivatives; Molecular modeling; Molecular model; Nanosphere; Quinolone derivatives; Cadmium Tellurides; Human; Urine; Scanning electron microscopy; Iron II Iron III Oxides; Healthy subject; Elimination; Theoretical study; Nanostructure; Norfloxacin; Magnetic particles; Transmission electron microscopy; Magnetic separation; Morphology; Preparation; Antibacterial agent; Ciprofloxacin; Fluorescent compound; Molecular imprinting; Silicon polymer
• ISSN: 1615-9306; 1615-9314; 1615-9314
• DOI: 10.1002/jssc.201401014

A magnetic molecularly imprinted fluorescent sensor for the sensitive and convenient determination of ciprofloxacin or norfloxacin in human urine was synthesized and characterized by scanning electron microscopy, Fourier transform infrared spectroscopy, X‐ray diffraction, ultraviolet/visible spectroscopy, and fluorescence spectroscopy. Both cadmium telluride quantum dots and ferroferric oxide nanoparticles are introduced into the polymer for the rapid separation and detection of the target molecules. The synthesized molecularly imprinted polymers were applied to detect ciprofloxacin or its structural analog norfloxacin in human urine with the detection limit 130 ng/mL. A computational study was developed to evaluate the template–monomer geometry and interaction energy in the polymerization mixture to determine the reaction molar ratio of the template and monomer molecules.