Structure of the Spiroketal-macrolide Ossamycin
Ossamycin is a cytotoxic agent of undetermined structure that was originally isolated in 1965 from culture broths of Streptomyces hygroscopicus var. ossamyceticus. Its overall structure and relative stereochemistry have now been determined by single crystal X-ray diffraction studies. Absolute stereo...
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Published in | Journal of antibiotics Vol. 49; no. 2; pp. 162 - 167 |
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Main Authors | , , , , , , , |
Format | Journal Article |
Language | English |
Published |
TOKYO
JAPAN ANTIBIOTICS RESEARCH ASSOCIATION
1996
JAPAN ANTIBIOT RES ASSN Japan Antibiotics Research Association |
Subjects | |
Online Access | Get full text |
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Summary: | Ossamycin is a cytotoxic agent of undetermined structure that was originally isolated in 1965 from culture broths of Streptomyces hygroscopicus var. ossamyceticus. Its overall structure and relative stereochemistry have now been determined by single crystal X-ray diffraction studies. Absolute stereochemistry was established according to the previously determined configuration of its aminosaccharide constituent, ossamine. The aglycone of ossamycin possesses a 24-membered macrolide ring system onto which is incorporated both a 6, 6-spiroketal and a 5-membered hemiketal ring system. The overall three-dimensional structure possesses features in common with the related macrocyclic antibiotics dunaimycin, cytovaricin, and A82548A. |
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Bibliography: | Medline NIH RePORTER ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-Feature-1 content type line 23 ObjectType-Article-1 ObjectType-Feature-2 |
ISSN: | 0021-8820 1881-1469 |
DOI: | 10.7164/antibiotics.49.162 |