ISOLATION OF DEALANYLALAHOPCIN, A NEW AMINO ACID, AND ITS BIOLOGICAL ACTIVITY

• Published in: Journal of antibiotics Vol. 38; no. 3; pp. 296 - 301
• Main Authors: HIGASHIDE, EIJI, KANAMARU, TSUNEO, FUKASE, HIROSHI, HORII, SATOSHI
• Format: Journal Article
• Language: English
• Published: Tokyo JAPAN ANTIBIOTICS RESEARCH ASSOCIATION 01.01.1985; Japan Antibiotics Research Association
• Subjects: Amino Acids - isolation & purification; Amino Acids - pharmacology; Aminobutyrates - isolation & purification; Aminobutyrates - pharmacology; Anti-Bacterial Agents - isolation & purification; Anti-Bacterial Agents - pharmacology; Antibiotics; Bacteria - drug effects; Biological and medical sciences; Biotechnology; Chemical Phenomena; Chemistry; dealanylalahopcin; Fundamental and applied biological sciences. Psychology; Health. Pharmaceutical industry; Hydrolysis; Industrial applications and implications. Economical aspects; Production of active biomolecules; Streptomyces - metabolism; Streptomyces albulus; Streptomyces albulus ochragerus; Aminoacid; Production; Enzyme inhibitor; Bacteria; Isolation; Antibacterial agent; Fermentation; Biological activity
• ISSN: 0021-8820; 1881-1469
• DOI: 10.7164/antibiotics.38.296

A new amino acid, dealanylalahopcin, was isolated from a culture filtrate of Streptomyces albulus subsp. ochragerus; it was also formed by the enzymatic hydrolysis of alahopcin using microbial α-amino acid ester hydrolase. The amino acid was obtained as colorless needles and its molecular formula is C6H10N2O5 It showed very weak antibacterial activity against Gram-positive and Gram-negative bacteria, and weak inhibitory activity against the collagen prolylhydroxylase.