Metabolism of Paeoniflorin and Related Compounds by Human Intestinal Bacteria

In the course of studies on the metabolism of active components of crude drugs by intestinal bacteria, paeoniflorin, oxypaeoniflorin, and benzoylpaeoniflorin isolated from the roots of Paeonia albiflora PALLAS (Paeoniaceae) were incubated with a human fecal suspension. Paeoniflorin, as well as oxypa...

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Published inChemical & pharmaceutical bulletin Vol. 33; no. 9; pp. 3838 - 3846
Main Authors HATTORI, MASAO, SHU, YUEZHONG, SHIMIZU, MINEO, HAYASHI, TOSHIMITSU, MORITA, NAOKATA, KOBASHI, KYOICHI, XU, GUOJUN, NAMBA, TSUNEO
Format Journal Article
LanguageEnglish
Published Tokyo The Pharmaceutical Society of Japan 01.01.1985
Maruzen
Japan Science and Technology Agency
Subjects
Bacteria - metabolism
Benzoates
Biological and medical sciences
Bridged-Ring Compounds
Chemical Phenomena
Chemistry
General pharmacology
Glucosides - metabolism
Glycosides - metabolism
Humans
Intestines - microbiology
Magnetic Resonance Spectroscopy
Male
Medical sciences
Monoterpenes
Peptostreptococcus anaerobius
Pharmacognosy. Homeopathy. Health food
Pharmacology. Drug treatments
Dicotyledones
Biotransformation
Angiospermae
Gut
Microflora
Spermatophyta
Metabolism
Paeoniaceae
Medicinal plant
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Summary:In the course of studies on the metabolism of active components of crude drugs by intestinal bacteria, paeoniflorin, oxypaeoniflorin, and benzoylpaeoniflorin isolated from the roots of Paeonia albiflora PALLAS (Paeoniaceae) were incubated with a human fecal suspension. Paeoniflorin, as well as oxypaeoniflorin and benzoylpaeoniflorin, was converted to three metabolites (paeonimetabolines I, II and III) by intestinal bacteria. The structure of the major metabolite (paeonimetaboline I) was elucidated by spectroscopic methods. Through screening of various strains of intestinal bacteria from human feces, Peptostreptococcus anaerobius was shown to have potent ability to transform paeoniflorin to paeonimetaboline I.
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ISSN:0009-2363
1347-5223
DOI:10.1248/cpb.33.3838