Clinical high risk and first episode schizophrenia: Auditory event-related potentials

Abstract The clinical high risk (CHR) period is a phase denoting a risk for overt psychosis during which subacute symptoms often appear, and cognitive functions may deteriorate. To compare biological indices during this phase with those during first episode schizophrenia, we cross-sectionally examin...

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Published inPsychiatry research. Neuroimaging Vol. 231; no. 2; pp. 126 - 133
Main Authors del Re, Elisabetta C, Spencer, Kevin M, Oribe, Naoya, Mesholam-Gately, Raquelle I, Goldstein, Jill, Shenton, Martha E, Petryshen, Tracey, Seidman, Larry J, McCarley, Robert W, Niznikiewicz, Margaret A
Format Journal Article
LanguageEnglish
Published Ireland Elsevier Ireland Ltd 28.02.2015
Subjects
Adult
Attention - physiology
Electroencephalography - methods
Event-Related Potentials, P300 - physiology
Evoked Potentials, Auditory - physiology
Female
Humans
Male
N100
P200
P3a
P3b
Psychiatry
Psychomotor Performance - physiology
Psychotic Disorders - psychology
Radiology
Risk
Schizophrenia - physiopathology
Young Adult
P3b
N100
P200
P3a
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Summary:Abstract The clinical high risk (CHR) period is a phase denoting a risk for overt psychosis during which subacute symptoms often appear, and cognitive functions may deteriorate. To compare biological indices during this phase with those during first episode schizophrenia, we cross-sectionally examined sex- and age-matched clinical high risk (CHR, n =21), first episode schizophrenia patients (FESZ, n =20) and matched healthy controls (HC, n =25) on oddball and novelty paradigms and assessed the N100, P200, P3a and P3b as indices of perceptual, attentional and working memory processes. To our knowledge, this is the only such comparison using all of these event-related potentials (ERPs) in two paradigms. We hypothesized that the ERPs would differentiate between the three groups and allow prediction of a diagnostic group. The majority of ERPs were significantly affected in CHR and FESZ compared with controls, with similar effect sizes. Nonetheless, in logistic regression, only the P3a and N100 distinguished CHR and FESZ from healthy controls, suggesting that ERPs not associated with an overt task might be more sensitive to prediction of group membership.
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ISSN:0925-4927
1872-7506
DOI:10.1016/j.pscychresns.2014.11.012