Structure of Ericamycin Having a 2-Azahexaphene Ring System

• Published in: Journal of antibiotics Vol. 51; no. 2; pp. 232 - 234
• Main Authors: KONDO, SHINICHI, IKEDA, YOKO, IKEDA, DAISHIRO, NISHIZUKA, TOSHIO, GOMI, SHUICHI
• Format: Journal Article
• Language: English
• Published: TOKYO JAPAN ANTIBIOTICS RESEARCH ASSOCIATION 1998; JAPAN ANTIBIOT RES ASSN; Japan Antibiotics Research Association
• Subjects: Anthracyclines; Antibacterial agents; Antibiotics (antibacterial agents, antifungal agents); Antibiotics, Antineoplastic - chemistry; Antibiotics, Antineoplastic - isolation & purification; Antibiotics, microbial producers, chemotherapic agents, antiseptics, disinfecting agents; Antibiotics. Antiinfectious agents. Antiparasitic agents; Applied microbiology; Biological and medical sciences; Biotechnology & Applied Microbiology; Fundamental and applied biological sciences. Psychology; Immunology; Life Sciences & Biomedicine; Medical sciences; Microbiology; Molecular Structure; Pharmacology & Pharmacy; Pharmacology. Drug treatments; Science & Technology; Streptomyces; Streptomyces varius; FERMENTATION; BIOLOGICAL-ACTIVITIES; ANTIFUNGAL ANTIBIOTICS; INHIBITORS; PRADIMICIN; Antibiotic; Microorganism culture; NMR spectrometry; Antibacterial agent; Fermentation; Mass spectrometry; Structural analysis; Circular dichroism
• ISSN: 0021-8820; 1881-1469
• DOI: 10.7164/antibiotics.51.232

An anti-staphylococcal antibiotic, ericamycin was found in the culture of Streptomyces varius n. sp. by a Meiji group in 1966. In the 30 years since the first isolation of this antibiotic, no attempt has been made to elucidate the structure. In this paper, the structure determination by the MS, NMR and CD spectral studies are presented.