Epidemiological evidence for early-onset of enzootic bovine leukosis by L233-Tax-carrying bovine leukemia virus in Japanese Black cattle

Bovine leukemia virus (BLV) is the causative agent of enzootic bovine leukosis (EBL), of which annual number has rapidly increased in Japan, and it can be divided into two categories based on the amino acid at position 233 in the Tax protein. Here, we conducted a nationwide surveillance of Japanese...

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Published inJournal of Veterinary Medical Science Vol. 84; no. 9; pp. 1216 - 1220
Main Authors TOMIYASU, Takafumi, MORI, Hiroshi, OKAZAKI, Katsunori
Format Journal Article
LanguageEnglish
Published Tokyo JAPANESE SOCIETY OF VETERINARY SCIENCE 2022
Japan Science and Technology Agency
The Japanese Society of Veterinary Science
Subjects
Age
Amino acids
bovine leukemia virus
Bovine leukosis
Embryo transfer
enzootic bovine leucosis
Epidemiology
Japanese Black cattle
Leukosis
Tax
Tax protein
Tumors
Virology
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Summary:Bovine leukemia virus (BLV) is the causative agent of enzootic bovine leukosis (EBL), of which annual number has rapidly increased in Japan, and it can be divided into two categories based on the amino acid at position 233 in the Tax protein. Here, we conducted a nationwide surveillance of Japanese Black cattle between 2008 and 2021 in Japan. Among 237 tumor samples, 131 (55.3%) and 101 (42.6%) were harbored L233- and P233-Tax, respectively. Onset of EBL under the age of 3 years by L233-Tax-carrying BLV was frequently observed, especially in the animals born via embryo transfer. We also found that L233-Tax-carrying BLV was more prevalent in dairy areas than non-dairy areas. These findings give insight into prevention of EBL.
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These authors contributed equally to this work.
ISSN:0916-7250
1347-7439
1347-7439
DOI:10.1292/jvms.22-0169