Reduction in HPV 16/18 prevalence in sexually active young women following the introduction of HPV immunisation in England

• Published in: Vaccine Vol. 32; no. 1; pp. 26 - 32
• Main Authors: Mesher, D, Soldan, K, Howell-Jones, R, Panwar, K, Manyenga, P, Jit, M, Beddows, S, Gill, O.N
• Format: Journal Article
• Language: English
• Published: Kidlington Elsevier Ltd 17.12.2013; Elsevier; Elsevier Limited; Elsevier Science
• Subjects: Adolescent; Adult; Age Factors; Allergy and Immunology; Applied microbiology; Biological and medical sciences; Cervarix; Cervical cancer; DNA; England - epidemiology; Family planning; Female; Fundamental and applied biological sciences. Psychology; genotyping; health services; HPV immunisation; HPV prevalence; Human papillomavirus; Human papillomavirus 16 - genetics; Human papillomavirus 16 - immunology; Human papillomavirus 18 - genetics; Human papillomavirus 18 - immunology; Humans; Immunization; Medical screening; Microbiology; Miscellaneous; monitoring; Odds Ratio; Papillomavirus Infections - epidemiology; Papillomavirus Infections - prevention & control; Papillomavirus Infections - transmission; Papillomavirus Vaccines - immunology; polymerase chain reaction; Prevalence; Risk Factors; screening; Sexual Behavior; Sexual health; Sexually transmitted diseases; STD; Surveillance; surveys; uterine cervical neoplasms; Vaccination; Vaccines; Vaccines, antisera, therapeutical immunoglobulins and monoclonal antibodies (general aspects); Virology; women; Young Adult; youth; England; United Kingdom; Great Britain; Europe; Western Europe; United Kingdom > UK; PCT; National Chlamydia Screening Programme; LR; HPV immunisation; HR; Linear Array; PHE; Lower Super Output Area; HPV; Research Ethics Committee; Vulva-vaginal Swab; VVS; PDH; HC2; General Practice; Polymerase Chain Reaction; Pyruvate dehydrogenase; Primary Care Trust; Hybrid Capture 2; High-risk; Cervarix; OR; Low-risk; CI; GP; REC; Confidence Interval; HPV prevalence; Surveillance; LA; NCSP; Odds ratio; LSOA; Human Papillomavirus; PCR; Public Health England; Human; Immunization; Prevalence; Vaccine; Papovaviridae; Epidemiology; Human papillomavirus 18; Papillomavirus; Virus; Human papillomavirus 16; Human papillomavirus; Female; Woman
• ISSN: 0264-410X; 1873-2518
• DOI: 10.1016/j.vaccine.2013.10.085

Highlights • We monitor HPV infection in sexually active young women in England. • The prevalence of HPV 16/18 has reduced within 3 years of HPV immunisation. • Reductions in HPV 16/18 were greatest at ages with highest immunisation coverage. • The data suggest reductions in HPV 16/18 amongst unvaccinated young women and men.