The Effect of Di- (2-ethylhexyl) phthalate, a Chemical Leached from Blood Bags, on Platelet Adenosine Diphosphate Aggregability

• Published in: Chemical & pharmaceutical bulletin Vol. 35; no. 10; pp. 4328 - 4331
• Main Authors: BANNAI, MAKOTO, MAZDA, TOSHIO, ISHIKAWA, YOSHIHIDE, SASAKAWA, SHIGERU
• Format: Journal Article
• Language: English
• Published: Tokyo The Pharmaceutical Society of Japan 1987; Maruzen; Japan Science and Technology Agency
• Subjects: Adenosine Diphosphate - pharmacology; ADP; aggregability; Applied sciences; blood bag; Blood Preservation; DEHP; Diethylhexyl Phthalate - pharmacology; Exact sciences and technology; Humans; In Vitro Techniques; Other techniques and industries; Phthalic Acids - pharmacology; platelet; Platelet Aggregation - drug effects; polyvinyl chloride; storage
• ISSN: 0009-2363; 1347-5223
• DOI: 10.1248/cpb.35.4328

Recovery of adenosine diphosphate aggregability of stored platelets took place after incubation at 37°C with Tyrode/bovine serum albumin solution as well as with fresh plasma. However, recovery with plasma from platelet concentrate (PC) stored in ordinary polyvinyl chloride bags was less, and the extent of the decrease depended upon the length of storage. The level of recovery with stored PC plasma, containing leached di- (2-ethylhexyl) phthalate (DEHP), was the same as that of fresh plasma to which DEHP had been added at the same concentration as found in the stored PC plasma. These results indicate that DEHP leached into the plasma of stored PC suppresses aggregability recovery. This suppression by DEHP is reversible.