上皮间充质转化介导子宫内膜异位症发生发展的研究进展

上皮间充质转化在子宫内膜异位症的发生和发展中扮演重要角色，间充质上皮转化参与内异症局部病灶的形成，上皮间充质转化参与内异症局部炎症损伤、修复和纤维化与细胞侵袭和转移的过程。通过研究上皮间充质转化在内异症进程中特征性的信号传导通路及分子蛋白，可以为发现内异症新的诊断和治疗方案提供思路。...

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Bibliographic Details
Published in浙江大学学报（医学版） Vol. 45; no. 4; pp. 439 - 445
Main Author 竺天虹 张信美
Format Journal Article
LanguageChinese
Published 浙江大学医学院附属妇产科医院,浙江杭州,310006 2016
Subjects
上皮细胞/病理学
中胚层/病理学
子宫内膜异位症/病理生理学
综述
中胚层/病理学
子宫内膜异位症/病理生理学
Epithelial cells/pathology
Mesoderm/pathology
上皮细胞/病理学
综述
Key words] Endometriosis/physiopathology
Review
Online AccessGet full text
ISSN1008-9292
DOI10.3785/j.issn.1008-9292.2016.07.17

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Summary:上皮间充质转化在子宫内膜异位症的发生和发展中扮演重要角色，间充质上皮转化参与内异症局部病灶的形成，上皮间充质转化参与内异症局部炎症损伤、修复和纤维化与细胞侵袭和转移的过程。通过研究上皮间充质转化在内异症进程中特征性的信号传导通路及分子蛋白，可以为发现内异症新的诊断和治疗方案提供思路。
Bibliography:Key words] Endometriosis/physiopathology;Epithelial cells/pathology;Mesoderm/pathology;Review
33-1248/R
Epithelial-mesenchymal transition plays an important role in the development and progression of endometriosis. Mesenchymal-epithelial transition is involved in forming localized lesions of endometriosis, while EMT is involved in the injury, repair and fibrosis induced by local inflammation of endometriosis and the process of cell invasion and metastasis.The studies of signal transduction pathway and related proteins of epithelial-mesenchymal transition in the process of endometriosis may provide new targets for diagnosis and treatment of endometriosis.
ZHU Tianhong, ZHANG Xinmei （Department of Gynecology, Women＇ s Hospital, Zhejiang University School of Medicine, Hangzhou 310006, China）
ISSN:1008-9292
DOI:10.3785/j.issn.1008-9292.2016.07.17