Inhibition of inlfammatory cytokines after early decompression may mediate recovery of neurological function in rats with spinal cord injury

• Published in: 中国神经再生研究（英文版） Vol. 10; no. 2; pp. 219 - 224
• Main Author: Jia-bing Xie Xin Zhang Quan-hui Li Zhu-jun Xu
• Format: Journal Article
• Language: English
• Published: Department of Trauma 0rthopedics, Yijishan Hospital Afifliated to Wannan Medical College, Wuhu, Anhui Province, China 2015
• Subjects: 介导; 减压; 大鼠模型; 急性脊髓损伤; 早期; 神经功能; 细胞因子; 肿瘤坏死因子; spinal cord injury; neurological function; neural regeneration; cell apoptosis; nerve regeneration; tumor necrosis factorα; surgical decompression
• ISSN: 1673-5374
• DOI: 10.4103/1673-5374.152374

A variety of inlfammatory cytokines are involved in spinal cord injury and inlfuence the recov-ery of neuronal function. In the present study, we established a rat model of acute spinal cord injury by cerclage. The cerclage suture was released 8 or 72 hours later, to simulate decompres-sion surgery. Neurological function was evaluated behaviorally for 3 weeks after surgery, and tumor necrosis factorα immunoreactivity and apoptosis were quantiifed in the region of injury. Rats that underwent decompression surgery had significantly weaker immunoreactivity of tumor necrosis factorα and signiifcantly fewer apoptotic cells, and showed faster improvement of locomotor function than animals in which decompression surgery was not performed. De-compression at 8 hours resulted in signiifcantly faster recovery than that at 72 hours. These data indicate that early decompression may improve neurological function after spinal cord injury by inhibiting the expression of tumor necrosis factorα.