Standard: Human intestinal organoids

Organoids have attracted great interest for disease modelling, drug discovery and development, and tissue growth and homeostasis investigations. However, lack of standards for quality control has become a prominent obstacle to limit their translation into clinic and other applications. “Human intest...

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Published inCell regeneration Vol. 12; no. 1; p. 23
Main Authors Wang, Yalong, Lin, Hanqing, Zhao, Lianzheng, Hong, Fan, Hao, Jie, Zhang, Zhen, Sheng, Weiqi, Song, Linhong, Deng, Chu-Xia, Zhao, Bing, Cao, Jiani, Wang, Lei, Wang, Liu, Liang, Lingmin, Chen, Wenli Kelly, Yu, Chunping, Sun, Zhijian, Yang, Yingying, Wang, Changlin, Zhang, Yong, Li, Qiyuan, Li, Ka, Ma, Aijin, Zhao, Tongbiao, Hua, Guoqiang, Chen, Ye-Guang
Format Journal Article
LanguageEnglish
Published Singapore Springer Nature Singapore 14.06.2023
Springer Nature B.V
SpringerOpen
Subjects
Acquired immune deficiency syndrome
AIDS
Biomedical and Life Sciences
Biomedicine
Cell Biology
Consent
Cryopreservation
Editorial
Epithelial cells
Ethics
Freezing
Gene expression
Genes
Hepatitis
Hepatitis B
Hepatitis C
HIV
Homeostasis
Human immunodeficiency virus
Intestine
Life Sciences
Low temperature
Microorganisms
Morphology
Organoids
Phosphatase
Quality control
Regenerative medicine
Standardization
Stem Cells
China
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Summary:Organoids have attracted great interest for disease modelling, drug discovery and development, and tissue growth and homeostasis investigations. However, lack of standards for quality control has become a prominent obstacle to limit their translation into clinic and other applications. “Human intestinal organoids” is the first guideline on human intestinal organoids in China, jointly drafted and agreed by the experts from the Chinese Society for Cell Biology and its branch society: the Chinese Society for Stem Cell Research. This standard specifies terms and definitions, technical requirements, test methods, inspection rules for human intestinal organoids, which is applicable to quality control during the process of manufacturing and testing of human intestinal organoids. It was originally released by the Chinese Society for Cell Biology on 24 September 2022. We hope that the publication of this standard will guide institutional establishment, acceptance and execution of proper practical protocols and accelerate the international standardization of human intestinal organoids for applications.
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ISSN:2045-9769
2045-9769
DOI:10.1186/s13619-023-00168-5