Impact of Coexisting Irritable Bowel Syndrome and Non-erosive Reflux Disease on Postprandial Abdominal Fullness and Sleep Disorders in Functional Dyspepsia

• Published in: Journal of Nippon Medical School Vol. 80; no. 5; pp. 362 - 370
• Main Authors: Futagami, Seiji, Yamawaki, Hiroshi, Shimpuku, Mayumi, Izumi, Nikki, Wakabayashi, Taiga, Kodaka, Yasuhiro, Nagoya, Hiroyuki, Shindo, Tomotaka, Kawagoe, Tetsuro, Sakamoto, Choitsu
• Format: Journal Article
• Language: English; Japanese
• Published: Japan The Medical Association of Nippon Medical School 2013
• Subjects: Breath Tests; Case-Control Studies; Comorbidity; Dyspepsia - diagnosis; Dyspepsia - epidemiology; Dyspepsia - physiopathology; functional dyspepsia; Gastric Emptying; gastric motility; Gastroesophageal Reflux - diagnosis; Gastroesophageal Reflux - epidemiology; Humans; Hunger; Irritable Bowel Syndrome - diagnosis; Irritable Bowel Syndrome - epidemiology; Japan - epidemiology; overlap syndrome; Postprandial Period; Prevalence; Psychiatric Status Rating Scales; Risk Factors; Sleep; sleep disorders; Sleep Wake Disorders - diagnosis; Sleep Wake Disorders - epidemiology; Sleep Wake Disorders - physiopathology; Surveys and Questionnaires; Japan
• ISSN: 1345-4676; 1347-3409
• DOI: 10.1272/jnms.80.362

Background/Aims: The association between clinical symptoms and sleep disorders in functional dyspepsia (FD)-overlap syndrome has not been studied in detail. Methods: The subjects were 139 patients with FD, 14 with irritable bowel syndrome (IBS), 12 with nonerosive reflux disease (NERD), and 41 healthy volunteers. Gastric motility was evaluated with the 13C-acetate breath test. We used Rome III criteria to evaluate upper abdominal symptoms, and Self-Rating Questionnaire for Depression (SRQ-D) scores to determine depression status. Sleep disorders were evaluated with Pittsburgh Sleep Quality Index (PSQI) scores. Results: There were no significant differences in age, body-mass index, alcohol intake, and smoking rate between patients with FD alone and those with FD-overlap syndrome. The postprandial abdominal fullness score in patients with FD-NERD-IBS was significantly greater than that in patients with FD-NERD overlap syndrome (p<0.001) or FD alone (p<0.001). The score for the feeling of hunger in patients with FD-NERD-IBS was significantly greater than that in patients with FD alone (p=0.0025), FD-NERD overlap syndrome (p=0.0088), or FD-IBS overlap syndrome (p=0.0057). The heartburn score in subjects with FD-NERD-IBS overlap syndrome was significantly greater than that in subjects with FD alone (p=0.0035) or FD-IBS overlap syndrome (p=0.0026). The Tmax in patients with FD-overlap syndrome or FD alone was significantly higher than that in healthy volunteers. The Pittsburgh Sleep Quality Index score in subjects with FD-NERD-IBS overlap syndrome was significantly greater than that in subjects with FD alone. Conclusion: Symptom scores, such as those for postprandial abdominal fullness, heartburn, and the feeling of hunger, in patients with FD-overlap syndromes are significantly greater than those in patients with FD alone. Further studies are necessary to clarify whether various symptoms are related to sleep disorders in patients with FD-NERD-IBS overlap syndrome.