The role of circular RNA circ_0008285 in gestational diabetes mellitus by regulating the biological functions of trophoblasts

Circular RNAs (circRNAs) has emerged as vital regulator involved in various diseases. In this study, we identified and investigated the potential circRNAs involved in gestational diabetes mellitus (GDM). High-throughput sequencing was used to collect the plasma circRNAs expression profiles of GDM pa...

Full description

Saved in:
Bibliographic Details
Published inBiological research Vol. 54; no. 1; pp. 14 - 12
Main Authors Chen, Haitian, Zhang, Shaofeng, Wu, Yanxin, Li, Zhuyu, Wang, Dongyu, Cai, Shiqin, Wang, Zilian
Format Journal Article
LanguageEnglish
Published England BioMed Central Ltd 20.04.2021
BioMed Central
Sociedad de Biología de Chile
BMC
Subjects
Binding sites
BIOLOGY
Biomarkers
Cancer
Cell culture
Cell growth
Cell proliferation
Cell Proliferation - genetics
Cholesterol
circ_0008285
Circular RNA
Diabetes in pregnancy
Diabetes mellitus
Diabetes, Gestational - genetics
Female
Functional analysis
Gestational diabetes
Gestational diabetes mellitus
Glucose
Glycosylated hemoglobin
Hemoglobin
Humans
Low density lipoprotein
Low density lipoproteins
Medical research
Medicine, Experimental
MicroRNA
MicroRNAs
MicroRNAs - genetics
miRNA
Multiple births
Next-generation sequencing
Obesity
Plasma
Polymerase chain reaction
Pregnancy
Reagents
RNA, Circular
Therapeutic targets
Trophoblasts
Type 2 diabetes
Womens health
China
United States > US
Gestational diabetes mellitus
Circular RNA
circ_0008285
Functional analysis
Online AccessGet full text

Cover

Abstract Circular RNAs (circRNAs) has emerged as vital regulator involved in various diseases. In this study, we identified and investigated the potential circRNAs involved in gestational diabetes mellitus (GDM). High-throughput sequencing was used to collect the plasma circRNAs expression profiles of GDM patients. Quantitative reverse-transcriptase polymerase chain reaction (qRT-PCR) was used to measure the expressions of circ_0008285 and circ_0001173 in the plasma specimens. The Pearson's correlation test was employed to assess the correlation between 2 circRNAs expression and the clinicopathologic data. Two circRNAs expression was verified in high glucose (HG)-induced HTR-8/SVneo cells. MTS, transwell assay was used to evaluate the effects of circ_0008285 expression on HG-induced HTR-8/SVneo cells. The network of circ_0008285 was constructed using cytocape. In GDM patients, the expression of circ_0008285 was significantly upregulated, while that of circ_0001173 was decreased. Circ_0008285 was significantly correlated with the total cholesterol and LDL-C levels. Circ_0001173 was significantly correlated with glycated hemoglobin. HG promoted the proliferation, invasion, and migration in HTR-8/SVneo cells, while the knockdown of circ_0008285 exerted reverse effects. In addition, network construction exhibited that circ_0008285 had 45 miRNA binding sites, which correlated with 444 mRNA. circ_0008285 plays an important role and provides a clue for the usage of therapeutic targets in the development of GDM.
AbstractList Abstract Background Circular RNAs (circRNAs) has emerged as vital regulator involved in various diseases. In this study, we identified and investigated the potential circRNAs involved in gestational diabetes mellitus (GDM). Methods High-throughput sequencing was used to collect the plasma circRNAs expression profiles of GDM patients. Quantitative reverse-transcriptase polymerase chain reaction (qRT-PCR) was used to measure the expressions of circ_0008285 and circ_0001173 in the plasma specimens. The Pearson’s correlation test was employed to assess the correlation between 2 circRNAs expression and the clinicopathologic data. Two circRNAs expression was verified in high glucose (HG)-induced HTR-8/SVneo cells. MTS, transwell assay was used to evaluate the effects of circ_0008285 expression on HG-induced HTR-8/SVneo cells. The network of circ_0008285 was constructed using cytocape. Results In GDM patients, the expression of circ_0008285 was significantly upregulated, while that of circ_0001173 was decreased. Circ_0008285 was significantly correlated with the total cholesterol and LDL-C levels. Circ_0001173 was significantly correlated with glycated hemoglobin. HG promoted the proliferation, invasion, and migration in HTR-8/SVneo cells, while the knockdown of circ_0008285 exerted reverse effects. In addition, network construction exhibited that circ_0008285 had 45 miRNA binding sites, which correlated with 444 mRNA. Conclusions circ_0008285 plays an important role and provides a clue for the usage of therapeutic targets in the development of GDM.
Circular RNAs (circRNAs) has emerged as vital regulator involved in various diseases. In this study, we identified and investigated the potential circRNAs involved in gestational diabetes mellitus (GDM).BACKGROUNDCircular RNAs (circRNAs) has emerged as vital regulator involved in various diseases. In this study, we identified and investigated the potential circRNAs involved in gestational diabetes mellitus (GDM).High-throughput sequencing was used to collect the plasma circRNAs expression profiles of GDM patients. Quantitative reverse-transcriptase polymerase chain reaction (qRT-PCR) was used to measure the expressions of circ_0008285 and circ_0001173 in the plasma specimens. The Pearson's correlation test was employed to assess the correlation between 2 circRNAs expression and the clinicopathologic data. Two circRNAs expression was verified in high glucose (HG)-induced HTR-8/SVneo cells. MTS, transwell assay was used to evaluate the effects of circ_0008285 expression on HG-induced HTR-8/SVneo cells. The network of circ_0008285 was constructed using cytocape.METHODSHigh-throughput sequencing was used to collect the plasma circRNAs expression profiles of GDM patients. Quantitative reverse-transcriptase polymerase chain reaction (qRT-PCR) was used to measure the expressions of circ_0008285 and circ_0001173 in the plasma specimens. The Pearson's correlation test was employed to assess the correlation between 2 circRNAs expression and the clinicopathologic data. Two circRNAs expression was verified in high glucose (HG)-induced HTR-8/SVneo cells. MTS, transwell assay was used to evaluate the effects of circ_0008285 expression on HG-induced HTR-8/SVneo cells. The network of circ_0008285 was constructed using cytocape.In GDM patients, the expression of circ_0008285 was significantly upregulated, while that of circ_0001173 was decreased. Circ_0008285 was significantly correlated with the total cholesterol and LDL-C levels. Circ_0001173 was significantly correlated with glycated hemoglobin. HG promoted the proliferation, invasion, and migration in HTR-8/SVneo cells, while the knockdown of circ_0008285 exerted reverse effects. In addition, network construction exhibited that circ_0008285 had 45 miRNA binding sites, which correlated with 444 mRNA.RESULTSIn GDM patients, the expression of circ_0008285 was significantly upregulated, while that of circ_0001173 was decreased. Circ_0008285 was significantly correlated with the total cholesterol and LDL-C levels. Circ_0001173 was significantly correlated with glycated hemoglobin. HG promoted the proliferation, invasion, and migration in HTR-8/SVneo cells, while the knockdown of circ_0008285 exerted reverse effects. In addition, network construction exhibited that circ_0008285 had 45 miRNA binding sites, which correlated with 444 mRNA.circ_0008285 plays an important role and provides a clue for the usage of therapeutic targets in the development of GDM.CONCLUSIONScirc_0008285 plays an important role and provides a clue for the usage of therapeutic targets in the development of GDM.
Circular RNAs (circRNAs) has emerged as vital regulator involved in various diseases. In this study, we identified and investigated the potential circRNAs involved in gestational diabetes mellitus (GDM). High-throughput sequencing was used to collect the plasma circRNAs expression profiles of GDM patients. Quantitative reverse-transcriptase polymerase chain reaction (qRT-PCR) was used to measure the expressions of circ_0008285 and circ_0001173 in the plasma specimens. The Pearson's correlation test was employed to assess the correlation between 2 circRNAs expression and the clinicopathologic data. Two circRNAs expression was verified in high glucose (HG)-induced HTR-8/SVneo cells. MTS, transwell assay was used to evaluate the effects of circ_0008285 expression on HG-induced HTR-8/SVneo cells. The network of circ_0008285 was constructed using cytocape. In GDM patients, the expression of circ_0008285 was significantly upregulated, while that of circ_0001173 was decreased. Circ_0008285 was significantly correlated with the total cholesterol and LDL-C levels. Circ_0001173 was significantly correlated with glycated hemoglobin. HG promoted the proliferation, invasion, and migration in HTR-8/SVneo cells, while the knockdown of circ_0008285 exerted reverse effects. In addition, network construction exhibited that circ_0008285 had 45 miRNA binding sites, which correlated with 444 mRNA. circ_0008285 plays an important role and provides a clue for the usage of therapeutic targets in the development of GDM.
Background Circular RNAs (circRNAs) has emerged as vital regulator involved in various diseases. In this study, we identified and investigated the potential circRNAs involved in gestational diabetes mellitus (GDM). Methods High-throughput sequencing was used to collect the plasma circRNAs expression profiles of GDM patients. Quantitative reverse-transcriptase polymerase chain reaction (qRT-PCR) was used to measure the expressions of circ_0008285 and circ_0001173 in the plasma specimens. The Pearson's correlation test was employed to assess the correlation between 2 circRNAs expression and the clinicopathologic data. Two circRNAs expression was verified in high glucose (HG)-induced HTR-8/SVneo cells. MTS, transwell assay was used to evaluate the effects of circ_0008285 expression on HG-induced HTR-8/SVneo cells. The network of circ_0008285 was constructed using cytocape. Results In GDM patients, the expression of circ_0008285 was significantly upregulated, while that of circ_0001173 was decreased. Circ_0008285 was significantly correlated with the total cholesterol and LDL-C levels. Circ_0001173 was significantly correlated with glycated hemoglobin. HG promoted the proliferation, invasion, and migration in HTR-8/SVneo cells, while the knockdown of circ_0008285 exerted reverse effects. In addition, network construction exhibited that circ_0008285 had 45 miRNA binding sites, which correlated with 444 mRNA. Conclusions circ_0008285 plays an important role and provides a clue for the usage of therapeutic targets in the development of GDM. Keywords: Circular RNA, Gestational diabetes mellitus, circ_0008285, Functional analysis
Circular RNAs (circRNAs) has emerged as vital regulator involved in various diseases. In this study, we identified and investigated the potential circRNAs involved in gestational diabetes mellitus (GDM). High-throughput sequencing was used to collect the plasma circRNAs expression profiles of GDM patients. Quantitative reverse-transcriptase polymerase chain reaction (qRT-PCR) was used to measure the expressions of circ_0008285 and circ_0001173 in the plasma specimens. The Pearson's correlation test was employed to assess the correlation between 2 circRNAs expression and the clinicopathologic data. Two circRNAs expression was verified in high glucose (HG)-induced HTR-8/SVneo cells. MTS, transwell assay was used to evaluate the effects of circ_0008285 expression on HG-induced HTR-8/SVneo cells. The network of circ_0008285 was constructed using cytocape. In GDM patients, the expression of circ_0008285 was significantly upregulated, while that of circ_0001173 was decreased. Circ_0008285 was significantly correlated with the total cholesterol and LDL-C levels. Circ_0001173 was significantly correlated with glycated hemoglobin. HG promoted the proliferation, invasion, and migration in HTR-8/SVneo cells, while the knockdown of circ_0008285 exerted reverse effects. In addition, network construction exhibited that circ_0008285 had 45 miRNA binding sites, which correlated with 444 mRNA. circ_0008285 plays an important role and provides a clue for the usage of therapeutic targets in the development of GDM.
Background Circular RNAs (circRNAs) has emerged as vital regulator involved in various diseases. In this study, we identified and investigated the potential circRNAs involved in gestational diabetes mellitus (GDM). Methods High-throughput sequencing was used to collect the plasma circRNAs expression profiles of GDM patients. Quantitative reverse-transcriptase polymerase chain reaction (qRT-PCR) was used to measure the expressions of circ_0008285 and circ_0001173 in the plasma specimens. The Pearson’s correlation test was employed to assess the correlation between 2 circRNAs expression and the clinicopathologic data. Two circRNAs expression was verified in high glucose (HG)-induced HTR-8/SVneo cells. MTS, transwell assay was used to evaluate the effects of circ_0008285 expression on HG-induced HTR-8/SVneo cells. The network of circ_0008285 was constructed using cytocape. Results In GDM patients, the expression of circ_0008285 was significantly upregulated, while that of circ_0001173 was decreased. Circ_0008285 was significantly correlated with the total cholesterol and LDL-C levels. Circ_0001173 was significantly correlated with glycated hemoglobin. HG promoted the proliferation, invasion, and migration in HTR-8/SVneo cells, while the knockdown of circ_0008285 exerted reverse effects. In addition, network construction exhibited that circ_0008285 had 45 miRNA binding sites, which correlated with 444 mRNA. Conclusions circ_0008285 plays an important role and provides a clue for the usage of therapeutic targets in the development of GDM.
ArticleNumber 14
Audience Academic
Author Wang, Dongyu
Wang, Zilian
Wu, Yanxin
Cai, Shiqin
Chen, Haitian
Li, Zhuyu
Zhang, Shaofeng
AuthorAffiliation Sun Yat-sen University
AuthorAffiliation_xml – name: Sun Yat-sen University
Author_xml – sequence: 1
  givenname: Haitian
  surname: Chen
  fullname: Chen, Haitian
– sequence: 2
  givenname: Shaofeng
  surname: Zhang
  fullname: Zhang, Shaofeng
– sequence: 3
  givenname: Yanxin
  surname: Wu
  fullname: Wu, Yanxin
– sequence: 4
  givenname: Zhuyu
  surname: Li
  fullname: Li, Zhuyu
– sequence: 5
  givenname: Dongyu
  surname: Wang
  fullname: Wang, Dongyu
– sequence: 6
  givenname: Shiqin
  surname: Cai
  fullname: Cai, Shiqin
– sequence: 7
  givenname: Zilian
  orcidid: 0000-0002-5866-7284
  surname: Wang
  fullname: Wang, Zilian
BackLink https://www.ncbi.nlm.nih.gov/pubmed/33879262$$D View this record in MEDLINE/PubMed
BookMark eNp9U8tq3DAUNSWlSab9gS6KoZt24VSSZUneFIbQx0BoIUnXQpZljwaNNZXk0Cz6770e5zVZFCOsxzlH9x7de5odDX4wWfYWozOMBfsUKWJVXSCCC4TKkhfli-wEccwLRgQ_ejI_zk5j3CBEKkTYq-y4LAWvCSMn2d_rtcmDdyb3Xa5t0KNTIb_8sdwvJEJIEFHldsh7E5NK1g_K5a1VjUkm5lvjnE1jzJvbPJgeyMkOfZ5AtLHe-d5qgHfjoCdmnC5Jwe_WvnEqpvg6e9kpF82bu_8i-_X1y_X59-Li57fV-fKi0KxkqVCM15TUGjHMdYcpLFvUCUqxKE3TcV51WHeqoabmolGqpoK3nWixaiqMOCoX2WrWbb3ayF2wWxVupVdW7jd86KUKyWpnpCCVQphUxOCWaiwE1kIjzgVtpzFpnc1aUVvjvNz4MYAnUV6B3UzWnCECTwLOwSCYAuHzTNiNzda02gwpKHcQxeHJYNey9zdSoIpVvAaBD3cCwf8e4Rnk1kYNzqvB-DFKUmFGSMlLAdD3z6AP4UFKQtRMIP6I6hVkbIfOw716EpVLxjDFtK7ZY6IHKPhas7UaSrGzsH9A-HhAAEwyf1Kvxhjl6uryEPvuqSkPbtxXJgDEDNDBxxhMJ7Wd6w-isE5iJKcmkHMTSHBa7psAFBYZeUa9V_8P6R-B5gPL
CitedBy_id crossref_primary_10_1155_2022_2169259
crossref_primary_10_1111_jcmm_16906
crossref_primary_10_3389_fendo_2023_1267195
crossref_primary_10_1002_mrd_23667
crossref_primary_10_1016_j_ncrna_2024_01_002
crossref_primary_10_1038_s41420_022_00913_w
crossref_primary_10_3390_biomedicines9111509
crossref_primary_10_1155_2022_9218113
crossref_primary_10_1016_j_bcp_2023_115456
crossref_primary_10_1080_21655979_2021_1967077
crossref_primary_10_1016_j_endinu_2022_09_003
crossref_primary_10_1080_10408444_2022_2144711
crossref_primary_10_1016_j_gene_2024_148894
crossref_primary_10_3389_fgene_2022_1050906
crossref_primary_10_3389_fgene_2021_749296
crossref_primary_10_12677_acm_2024_1461911
crossref_primary_10_1007_s43032_021_00687_z
crossref_primary_10_1016_j_endien_2023_02_003
crossref_primary_10_3390_ijms23094551
crossref_primary_10_1093_bib_bbac155
crossref_primary_10_3389_fendo_2022_885650
crossref_primary_10_4103_epj_epj_296_23
crossref_primary_10_3389_fgene_2022_1006307
crossref_primary_10_1007_s11033_023_08993_2
crossref_primary_10_1007_s10528_024_10789_3
crossref_primary_10_1002_mco2_699
crossref_primary_10_1007_s00210_024_03250_0
crossref_primary_10_1186_s12967_021_03195_5
Cites_doi 10.1007/s13300-020-00865-3
10.1186/s12958-020-00612-0
10.1002/dmrr.2803
10.3390/cells9071616
10.1016/j.omtm.2020.05.027
10.1007/s00125-018-4775-z
10.1016/j.canlet.2018.01.011
10.1507/endocrj.EJ18-0291
10.1186/s12935-020-01367-9
10.1007/s11010-011-0898-y
10.1007/978-1-62703-748-8_14
10.1007/s00125-016-3985-5
10.2147/CMAR.S244317
10.1186/s12943-020-01152-2
10.1111/1759-7714.13873
10.1080/15476286.2020.1790198
10.1002/ijgo.13178
10.1039/C4MB00287C
10.1007/s00592-015-0796-y
10.1016/j.bbrc.2018.03.051
10.1007/s43032-019-00010-x
10.1186/s12884-020-03068-7
10.3390/ijms21145003
10.1093/nar/gkm415
10.1038/nmeth1079
10.1186/s13046-020-01790-w
10.1186/s12575-020-00122-8
10.1016/j.jogoh.2019.101628
10.3390/ijms21114020
10.1080/14767058.2019.1610379
10.1016/j.bbrc.2020.03.165
10.1016/j.jdiacomp.2014.03.010
10.1186/s12864-020-06822-5
ContentType Journal Article
Copyright COPYRIGHT 2021 BioMed Central Ltd.
2021. This work is licensed under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.
The Author(s) 2021
This work is licensed under a Creative Commons Attribution 4.0 International License.
Copyright_xml – notice: COPYRIGHT 2021 BioMed Central Ltd.
– notice: 2021. This work is licensed under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.
– notice: The Author(s) 2021
– notice: This work is licensed under a Creative Commons Attribution 4.0 International License.
DBID AAYXX
CITATION
CGR
CUY
CVF
ECM
EIF
NPM
ISR
INF
3V.
7X7
7XB
88E
8FE
8FH
8FI
8FJ
8FK
ABUWG
AFKRA
AZQEC
BBNVY
BENPR
BHPHI
CCPQU
DWQXO
FYUFA
GHDGH
GNUQQ
HCIFZ
K9.
LK8
M0S
M1P
M7P
PHGZM
PHGZT
PIMPY
PJZUB
PKEHL
PPXIY
PQEST
PQGLB
PQQKQ
PQUKI
PRINS
7X8
5PM
GPN
DOA
DOI 10.1186/s40659-021-00337-3
DatabaseName CrossRef
Medline
MEDLINE
MEDLINE (Ovid)
MEDLINE
MEDLINE
PubMed
Gale In Context: Science
Informe Academico
ProQuest Central (Corporate)
Health & Medical Collection
ProQuest Central (purchase pre-March 2016)
Medical Database (Alumni Edition)
ProQuest SciTech Collection
ProQuest Natural Science Collection
Hospital Premium Collection
Hospital Premium Collection (Alumni Edition)
ProQuest Central (Alumni) (purchase pre-March 2016)
ProQuest Central (Alumni)
ProQuest Central UK/Ireland
ProQuest Central Essentials
Biological Science Collection
ProQuest Central
Natural Science Collection
ProQuest One
ProQuest Central Korea
Health Research Premium Collection
Health Research Premium Collection (Alumni)
ProQuest Central Student
SciTech Premium Collection
ProQuest Health & Medical Complete (Alumni)
Biological Sciences
ProQuest Health & Medical Collection
Medical Database
Biological Science Database
ProQuest Central Premium
ProQuest One Academic
Publicly Available Content Database
ProQuest Health & Medical Research Collection
ProQuest One Academic Middle East (New)
ProQuest One Health & Nursing
ProQuest One Academic Eastern Edition (DO NOT USE)
ProQuest One Applied & Life Sciences
ProQuest One Academic
ProQuest One Academic UKI Edition
ProQuest Central China
MEDLINE - Academic
PubMed Central (Full Participant titles)
SciELO
DOAJ Directory of Open Access Journals
DatabaseTitle CrossRef
MEDLINE
Medline Complete
MEDLINE with Full Text
PubMed
MEDLINE (Ovid)
Publicly Available Content Database
ProQuest Central Student
ProQuest One Academic Middle East (New)
ProQuest Central Essentials
ProQuest Health & Medical Complete (Alumni)
ProQuest Central (Alumni Edition)
SciTech Premium Collection
ProQuest One Community College
ProQuest One Health & Nursing
ProQuest Natural Science Collection
ProQuest Central China
ProQuest Central
ProQuest One Applied & Life Sciences
ProQuest Health & Medical Research Collection
Health Research Premium Collection
Health and Medicine Complete (Alumni Edition)
Natural Science Collection
ProQuest Central Korea
Health & Medical Research Collection
Biological Science Collection
ProQuest Central (New)
ProQuest Medical Library (Alumni)
ProQuest Biological Science Collection
ProQuest One Academic Eastern Edition
ProQuest Hospital Collection
Health Research Premium Collection (Alumni)
Biological Science Database
ProQuest SciTech Collection
ProQuest Hospital Collection (Alumni)
ProQuest Health & Medical Complete
ProQuest Medical Library
ProQuest One Academic UKI Edition
ProQuest One Academic
ProQuest One Academic (New)
ProQuest Central (Alumni)
MEDLINE - Academic
DatabaseTitleList
MEDLINE - Academic

MEDLINE


Publicly Available Content Database
Database_xml – sequence: 1
  dbid: DOA
  name: DOAJ Directory of Open Access Journals
  url: https://www.doaj.org/
  sourceTypes: Open Website
– sequence: 2
  dbid: NPM
  name: PubMed
  url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed
  sourceTypes: Index Database
– sequence: 3
  dbid: EIF
  name: MEDLINE
  url: https://proxy.k.utb.cz/login?url=https://www.webofscience.com/wos/medline/basic-search
  sourceTypes: Index Database
– sequence: 4
  dbid: BENPR
  name: ProQuest Central
  url: https://www.proquest.com/central
  sourceTypes: Aggregation Database
DeliveryMethod fulltext_linktorsrc
Discipline Biology
EISSN 0717-6287
EndPage 12
ExternalDocumentID oai_doaj_org_article_825a01252e1d4c1881c8c07784d784d0
S0716_97602021000100214
PMC8056579
A661414996
33879262
10_1186_s40659_021_00337_3
Genre Journal Article
GeographicLocations China
United States--US
GeographicLocations_xml – name: China
– name: United States--US
GrantInformation_xml – fundername: National Natural Science Foundation of China
  grantid: 81571452
– fundername: National Natural Science Foundation of China
  grantid: 81771606
– fundername: Natural Science Foundation of Guangdong Province
  grantid: 2015A030313198
– fundername: National Key R&D Program of China
  grantid: 2018YFC1002900
– fundername: Youth Cultivation Project of Sun Yat-sen University, China
  grantid: 17ykpy24
– fundername: Natural Science Foundation of Guangdong Province
  grantid: 2021A1515010411
– fundername: ;
  grantid: 17ykpy24
– fundername: ;
  grantid: 81771606; 81571452
– fundername: ;
  grantid: 2021A1515010411; 2015A030313198
– fundername: ;
  grantid: 2018YFC1002900
GroupedDBID ---
0R~
23N
2WC
4.4
53G
5GY
7X7
88E
8FE
8FH
8FI
8FJ
AAFWJ
AAJSJ
AASML
AAYXX
ABUWG
ABXHO
ACGFO
ACGFS
ACPRK
ADBBV
ADRAZ
ADUKV
AENEX
AFKRA
AFPKN
AHBYD
AHMBA
AHYZX
ALIPV
ALMA_UNASSIGNED_HOLDINGS
AMKLP
AMTXH
AOIJS
APOWU
ASPBG
AVWKF
AZFZN
BAPOH
BAWUL
BBNVY
BCNDV
BENPR
BFQNJ
BHPHI
BMC
BPHCQ
BVXVI
C6C
CCPQU
CITATION
DIK
DU5
E3Z
EBLON
EBS
ECGQY
F5P
FYUFA
GROUPED_DOAJ
GX1
HCIFZ
HMCUK
HYE
IAO
IHR
INF
ISR
ITC
KQ8
LK8
M1P
M48
M7P
OK1
OVT
P2P
PGMZT
PHGZM
PHGZT
PIMPY
PQQKQ
PROAC
PSQYO
RBZ
RNS
ROL
RPM
RSD
RSV
SCD
SOJ
TR2
UKHRP
XSB
CGR
CUY
CVF
ECM
EIF
NPM
PMFND
3V.
7XB
8FK
AZQEC
DWQXO
GNUQQ
K9.
PJZUB
PKEHL
PPXIY
PQEST
PQGLB
PQUKI
PRINS
7X8
5PM
AHSBF
C1A
EJD
GPN
H13
PUEGO
ID FETCH-LOGICAL-c636t-a679429c0617cf14679d0f844183ebf775f1cfab4e978baa9487df8d1ab510703
IEDL.DBID M48
ISSN 0717-6287
0716-9760
IngestDate Wed Aug 27 01:31:13 EDT 2025
Tue Aug 19 13:45:22 EDT 2025
Thu Aug 21 14:08:30 EDT 2025
Tue Aug 05 10:52:12 EDT 2025
Fri Jul 25 11:51:25 EDT 2025
Tue Jun 17 21:09:42 EDT 2025
Tue Jun 10 20:54:10 EDT 2025
Fri Jun 27 05:00:02 EDT 2025
Thu Apr 03 07:00:23 EDT 2025
Thu Apr 24 22:57:28 EDT 2025
Tue Jul 01 01:53:47 EDT 2025
IsDoiOpenAccess true
IsOpenAccess true
IsPeerReviewed true
IsScholarly true
Issue 1
Keywords Gestational diabetes mellitus
Circular RNA
circ_0008285
Functional analysis
Language English
License Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
This work is licensed under a Creative Commons Attribution 4.0 International License. http://creativecommons.org/licenses/by/4.0
LinkModel DirectLink
MergedId FETCHMERGED-LOGICAL-c636t-a679429c0617cf14679d0f844183ebf775f1cfab4e978baa9487df8d1ab510703
Notes ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 14
content type line 23
ORCID 0000-0002-5866-7284
OpenAccessLink https://www.proquest.com/docview/2528896807?pq-origsite=%requestingapplication%
PMID 33879262
PQID 2528896807
PQPubID 2040165
PageCount 12
ParticipantIDs doaj_primary_oai_doaj_org_article_825a01252e1d4c1881c8c07784d784d0
scielo_journals_S0716_97602021000100214
pubmedcentral_primary_oai_pubmedcentral_nih_gov_8056579
proquest_miscellaneous_2516223738
proquest_journals_2528896807
gale_infotracmisc_A661414996
gale_infotracacademiconefile_A661414996
gale_incontextgauss_ISR_A661414996
pubmed_primary_33879262
crossref_citationtrail_10_1186_s40659_021_00337_3
crossref_primary_10_1186_s40659_021_00337_3
ProviderPackageCode CITATION
AAYXX
PublicationCentury 2000
PublicationDate 2021-04-20
PublicationDateYYYYMMDD 2021-04-20
PublicationDate_xml – month: 04
  year: 2021
  text: 2021-04-20
  day: 20
PublicationDecade 2020
PublicationPlace England
PublicationPlace_xml – name: England
– name: Santiago
– name: London
PublicationTitle Biological research
PublicationTitleAlternate Biol Res
PublicationYear 2021
Publisher BioMed Central Ltd
BioMed Central
Sociedad de Biología de Chile
BMC
Publisher_xml – name: BioMed Central Ltd
– name: BioMed Central
– name: Sociedad de Biología de Chile
– name: BMC
References MS Ebert (337_CR13) 2007; 4
TR Magee (337_CR29) 2014; 28
A García-Claver (337_CR7) 2020; 150
M Adnan (337_CR25) 2011; 357
A Goyal (337_CR5) 2020; 11
B Chen (337_CR9) 2018; 418
L Yan (337_CR23) 2018; 498
C Zhao (337_CR6) 2015; 52
PT Mumtaz (337_CR12) 2020; 22
Q Lei (337_CR4) 2016; 32
R Retnakaran (337_CR3) 2019; 62
HY Peng (337_CR24) 2020; 27
Z Wu (337_CR33) 2021; 34
T Filardi (337_CR16) 2020; 21
T Jakobi (337_CR15) 2020; 9
Q Niu (337_CR26) 2020; 39
FM Awan (337_CR10) 2021; 18
J Du (337_CR32) 2014; 10
HY Zong (337_CR37) 2019; 23
L Meghelli (337_CR30) 2020; 49
HX Li (337_CR35) 2020; 24
X Yang (337_CR14) 2020; 20
H Wang (337_CR21) 2020; 18
Y Li (337_CR11) 2020; 21
S Ren (337_CR31) 2020; 18
G Liang (337_CR19) 2020; 19
Y Xing (337_CR36) 2019; 54
EU Alejandro (337_CR1) 2020; 21
Y Bai (337_CR18) 2020; 12
J Wang (337_CR17) 2020; 527
H Wang (337_CR22) 2019; 66
DW Huang (337_CR28) 2007; 35
P Damm (337_CR2) 2016; 59
Q Wu (337_CR20) 2021
B Akgül (337_CR27) 2014; 1107
HH Ye (337_CR34) 2018; 22
M Amini (337_CR8) 2020; 20
Peng, HY; Li, HP; Li, MQ 2020; 27
Goyal, A; Gupta, Y; Singla, R; Kalra, S; Tandon, N 2020; 11
Adnan, M; Morton, G; Hadi, S 2011; 357
Magee, TR; Ross, MG; Wedekind, L; Desai, M; Kjos, S; Belkacemi, L 2014; 28
Yan, L; Feng, J; Cheng, F; Cui, X; Gao, L; Chen, Y; Wang, F; Zhong, T; Li, Y; Liu, L 2018; 498
Lei, Q; Niu, J; Lv, L; Duan, D; Wen, J; Lin, X; Mai, C; Zhou, Y 2016; 32
Jakobi, T; Siede, D; Eschenbach, J; Heumüller, AW; Busch, M; Nietsch, R; Meder, B; Most, P; Dimmeler, S; Backs, J; Katus, HA; Dieterich, C 2020; 9
Ebert, MS; Neilson, JR; Sharp, PA 2007; 4
Liang, G; Ling, Y; Mehrpour, M; Saw, PE; Liu, Z; Tan, W; Tian, Z; Zhong, W; Lin, W; Luo, Q; Lin, Q; Li, Q; Zhou, Y; Hamai, A; Codogno, P; Li, J; Song, E; Gong, C 2020; 19
Yang, X; Mei, J; Wang, H; Gu, D; Ding, J; Liu, C 2020; 20
Wu, Z; Mao, W; Yang, Z; Lei, D; Huang, J; Fan, C; Suqing, W 2021; 34
Damm, P; Houshmand-Oeregaard, A; Kelstrup, L; Lauenborg, J; Mathiesen, ER; Clausen, TD 2016; 59
Retnakaran, R; Luo, J; Shah, BR 2019; 62
Li, HX; Li, XH; Jiang, J; Shi, PX; Zhang, XG; Tian, M 2020; 24
Bai, Y; Li, X 2020; 12
Ye, HH; Yang, SH; Zhang, Y 2018; 22
Huang, DW; Sherman, BT; Tan, Q; Kir, J; Liu, D; Bryant, D; Guo, Y; Stephens, R; Baseler, MW; Lane, HC; Lempicki, RA 2007; 35
Wang, H; Zhou, W; She, G; Yu, B; Sun, L 2020; 18
Akgül, B; Göktaş, C 2014; 1107
Mumtaz, PT; Taban, Q; Dar, MA; Mir, S; Haq, ZU; Zargar, SM; Shah, RA; Ahmad, SM 2020; 22
Li, Y; Ashraf, U; Chen, Z; Zhou, D; Imran, M; Ye, J; Chen, H; Cao, S 2020; 21
Niu, Q; Dong, Z; Liang, M; Luo, Y; Lin, H; Lin, M; Zhong, X; Yao, W; Weng, J; Zhou, X 2020; 39
Du, J; Yuan, Z; Ma, Z; Song, J; Xie, X; Chen, Y 2014; 10
Amini, M; Kazemnejad, A; Zayeri, F; Montazeri, A; Rasekhi, A; Amirian, A; Kariman, N 2020; 20
Zhao, C; Wang, F; Wang, P; Ding, H; Huang, X; Shi, Z 2015; 52
Chen, B; Huang, S 2018; 418
Alejandro, EU; Mamerto, TP; Chung, G; Villavieja, A; Gaus, NL; Morgan, E; Pineda-Cortel, MRB 2020; 21
García-Claver, A; Ramos-Corral, R; Laviña-Fañanás, C; Solans-Blecua, I; PuzoFoncillas, J 2020; 150
Awan, FM; Yang, BB; Naz, A; Hanif, A; Ikram, A; Obaid, A; Malik, A; Janjua, HA; Ali, A; Sharif, S 2021; 18
Meghelli, L; Vambergue, A; Drumez, E; Deruelle, P 2020; 49
Zong, HY; Wang, EL; Han, YM; Wang, QJ; Wang, JL; Wang, Z 2019; 23
Wang, J; Luo, J; Liu, G; Li, X 2020; 527
Ren, S; Lin, P; Wang, J; Yu, H; Lv, T; Sun, L; Du, G 2020; 18
Filardi, T; Catanzaro, G; Mardente, S; Zicari, A; Santangelo, C; Lenzi, A; Morano, S; Ferretti, E 2020; 21
Wu, Q; Luo, X; Li, H; Zhang, L; Su, F; Hou, S; Yin, J; Zhang, W; Zou, L 2021
Wang, H; She, G; Zhou, W; Liu, K; Miao, J; Yu, B 2019; 66
Xing, Y; Ren, S; Ai, L; Sun, W; Zhao, Z; Jiang, F; Zhu, Y; Piao, D 2019; 54
References_xml – volume: 11
  start-page: 1639
  year: 2020
  ident: 337_CR5
  publication-title: Diabetes Ther
  doi: 10.1007/s13300-020-00865-3
– volume: 18
  start-page: 51
  year: 2020
  ident: 337_CR21
  publication-title: Reprod Biol Endocrinol
  doi: 10.1186/s12958-020-00612-0
– volume: 32
  start-page: 835
  year: 2016
  ident: 337_CR4
  publication-title: Diabetes Metab Res Rev
  doi: 10.1002/dmrr.2803
– volume: 9
  start-page: 1616
  year: 2020
  ident: 337_CR15
  publication-title: Cells.
  doi: 10.3390/cells9071616
– volume: 18
  start-page: 215
  year: 2020
  ident: 337_CR31
  publication-title: Mol Ther Methods Clin Dev
  doi: 10.1016/j.omtm.2020.05.027
– volume: 62
  start-page: 306
  year: 2019
  ident: 337_CR3
  publication-title: Diabetologia
  doi: 10.1007/s00125-018-4775-z
– volume: 418
  start-page: 41
  year: 2018
  ident: 337_CR9
  publication-title: Cancer Lett
  doi: 10.1016/j.canlet.2018.01.011
– volume: 54
  start-page: 1691
  year: 2019
  ident: 337_CR36
  publication-title: Int J Oncol
– volume: 66
  start-page: 431
  year: 2019
  ident: 337_CR22
  publication-title: Endocr J
  doi: 10.1507/endocrj.EJ18-0291
– volume: 23
  start-page: 2325
  year: 2019
  ident: 337_CR37
  publication-title: Eur Rev Med Pharmacol Sci
– volume: 20
  start-page: 265
  year: 2020
  ident: 337_CR14
  publication-title: Cancer Cell Int
  doi: 10.1186/s12935-020-01367-9
– volume: 357
  start-page: 275
  year: 2011
  ident: 337_CR25
  publication-title: Mol Cell Biochem
  doi: 10.1007/s11010-011-0898-y
– volume: 1107
  start-page: 233
  year: 2014
  ident: 337_CR27
  publication-title: Methods Mol Biol
  doi: 10.1007/978-1-62703-748-8_14
– volume: 59
  start-page: 1396
  year: 2016
  ident: 337_CR2
  publication-title: Diabetologia
  doi: 10.1007/s00125-016-3985-5
– volume: 12
  start-page: 3927
  year: 2020
  ident: 337_CR18
  publication-title: Cancer Manag Res
  doi: 10.2147/CMAR.S244317
– volume: 19
  start-page: 65
  year: 2020
  ident: 337_CR19
  publication-title: Mol Cancer
  doi: 10.1186/s12943-020-01152-2
– year: 2021
  ident: 337_CR20
  publication-title: Thorac Cancer.
  doi: 10.1111/1759-7714.13873
– volume: 18
  start-page: 1
  year: 2021
  ident: 337_CR10
  publication-title: RNA Biol
  doi: 10.1080/15476286.2020.1790198
– volume: 150
  start-page: 234
  year: 2020
  ident: 337_CR7
  publication-title: Int J Gynaecol Obstet
  doi: 10.1002/ijgo.13178
– volume: 10
  start-page: 2441
  year: 2014
  ident: 337_CR32
  publication-title: Mol Biosyst
  doi: 10.1039/C4MB00287C
– volume: 52
  start-page: 1103
  year: 2015
  ident: 337_CR6
  publication-title: Acta Diabetol
  doi: 10.1007/s00592-015-0796-y
– volume: 498
  start-page: 743
  year: 2018
  ident: 337_CR23
  publication-title: Biochem Biophys Res Commun
  doi: 10.1016/j.bbrc.2018.03.051
– volume: 27
  start-page: 233
  year: 2020
  ident: 337_CR24
  publication-title: Reprod Sci
  doi: 10.1007/s43032-019-00010-x
– volume: 20
  start-page: 375
  year: 2020
  ident: 337_CR8
  publication-title: BMC Pregnancy Childbirth
  doi: 10.1186/s12884-020-03068-7
– volume: 21
  start-page: 5003
  year: 2020
  ident: 337_CR1
  publication-title: Int J Mol Sci.
  doi: 10.3390/ijms21145003
– volume: 35
  start-page: W169
  year: 2007
  ident: 337_CR28
  publication-title: Nucleic Acids Res
  doi: 10.1093/nar/gkm415
– volume: 4
  start-page: 721
  year: 2007
  ident: 337_CR13
  publication-title: Nat Methods
  doi: 10.1038/nmeth1079
– volume: 39
  start-page: 280
  year: 2020
  ident: 337_CR26
  publication-title: J Exp Clin Cancer Res
  doi: 10.1186/s13046-020-01790-w
– volume: 22
  start-page: 10
  year: 2020
  ident: 337_CR12
  publication-title: Biol Proced Online
  doi: 10.1186/s12575-020-00122-8
– volume: 24
  start-page: 1609
  year: 2020
  ident: 337_CR35
  publication-title: Eur Rev Med Pharmacol Sci
– volume: 49
  start-page: 101628
  year: 2020
  ident: 337_CR30
  publication-title: J Gynecol Obstet Hum Reprod
  doi: 10.1016/j.jogoh.2019.101628
– volume: 21
  start-page: 4020
  year: 2020
  ident: 337_CR16
  publication-title: Int J Mol Sci.
  doi: 10.3390/ijms21114020
– volume: 34
  start-page: 500
  year: 2021
  ident: 337_CR33
  publication-title: J Matern Fetal Neonatal Med
  doi: 10.1080/14767058.2019.1610379
– volume: 527
  start-page: 503
  year: 2020
  ident: 337_CR17
  publication-title: Biochem Biophys Res Commun
  doi: 10.1016/j.bbrc.2020.03.165
– volume: 28
  start-page: 448
  year: 2014
  ident: 337_CR29
  publication-title: J Diabetes Complications
  doi: 10.1016/j.jdiacomp.2014.03.010
– volume: 21
  start-page: 409
  year: 2020
  ident: 337_CR11
  publication-title: BMC Genomics
  doi: 10.1186/s12864-020-06822-5
– volume: 22
  start-page: 8553
  year: 2018
  ident: 337_CR34
  publication-title: Eur Rev Med Pharmacol Sci
– volume: 11
  start-page: 1639
  year: 2020
  end-page: 1644
  article-title: American Diabetes Association “Standards of Medical Care-2020 for Gestational Diabetes Mellitus”: a critical appraisal
  publication-title: Diabetes Ther
– volume: 18
  start-page: 1
  year: 2021
  end-page: 15
  article-title: The emerging role and significance of circular RNAs in viral infections and antiviral immune responses: possible implication as theranostic agents
  publication-title: RNA Biol
– volume: 59
  start-page: 1396
  year: 2016
  end-page: 1399
  article-title: Gestational diabetes mellitus and long-term consequences for mother and offspring: a view from Denmark
  publication-title: Diabetologia
– volume: 27
  start-page: 233
  year: 2020
  end-page: 245
  article-title: Downregulated ABHD5 aggravates insulin resistance of trophoblast cells during gestational diabetes mellitus
  publication-title: Reprod Sci
– volume: 34
  start-page: 500
  year: 2021
  end-page: 511
  article-title: Knockdown of CYP1B1 suppresses the behavior of the extravillous trophoblast cell line HTR-8/SVneo under hyperglycemic condition
  publication-title: J Matern Fetal Neonatal Med
– volume: 12
  start-page: 3927
  year: 2020
  end-page: 3936
  article-title: hsa_circ_0008285 facilitates the progression of cervical cancer by targeting miR-211-5p/SOX4 Axis
  publication-title: Cancer Manag Res
– volume: 1107
  start-page: 233
  year: 2014
  end-page: 242
  article-title: Gene reporter assay to validate microRNA targets in Drosophila S2 cells
  publication-title: Methods Mol Biol
– volume: 527
  start-page: 503
  year: 2020
  end-page: 510
  article-title: Circular RNA hsa_circ_0008285 inhibits colorectal cancer cell proliferation and migration via the miR-382-5p/PTEN axis
  publication-title: Biochem Biophys Res Commun
– volume: 22
  start-page: 10
  year: 2020
  end-page: 10
  article-title: Deep insights in Circular RNAs: from biogenesis to therapeutics
  publication-title: Biol Proced Online
– volume: 35
  start-page: W169
  year: 2007
  end-page: W175
  article-title: DAVID bioinformatics resources: expanded annotation database and novel algorithms to better extract biology from large gene lists
  publication-title: Nucleic Acids Res
– volume: 21
  start-page: 409
  year: 2020
  end-page: 409
  article-title: Genome-wide profiling of host-encoded circular RNAs highlights their potential role during the Japanese encephalitis virus-induced neuroinflammatory response
  publication-title: BMC Genomics
– volume: 150
  start-page: 234
  year: 2020
  end-page: 240
  article-title: Capillary glucose concentration during oral glucose tolerance test for the diagnosis of gestational diabetes
  publication-title: Int J Gynaecol Obstet
– volume: 9
  start-page: 1616
  year: 2020
  end-page: 1616
  article-title: Deep characterization of circular RNAs from human cardiovascular cell models and cardiac tissue
  publication-title: Cells
– volume: 66
  start-page: 431
  year: 2019
  end-page: 441
  article-title: Expression profile of circular RNAs in placentas of women with gestational diabetes mellitus
  publication-title: Endocr J
– volume: 49
  start-page: 101628
  year: 2020
  end-page: 101628
  article-title: Complications of pregnancy in morbidly obese patients: what is the impact of gestational diabetes mellitus?
  publication-title: J Gynecol Obstet Hum Reprod
– volume: 22
  start-page: 8553
  year: 2018
  end-page: 8560
  article-title: MEG3 damages fetal endothelial function induced by gestational diabetes mellitus via AKT pathway
  publication-title: Eur Rev Med Pharmacol Sci
– volume: 32
  start-page: 835
  year: 2016
  end-page: 842
  article-title: Clustering of metabolic risk factors and adverse pregnancy outcomes: a prospective cohort study
  publication-title: Diabetes Metab Res Rev
– volume: 21
  start-page: 4020
  year: 2020
  end-page: 4020
  article-title: Non-coding RNA: role in gestational diabetes pathophysiology and complications
  publication-title: Int J Mol Sci
– volume: 20
  start-page: 375
  year: 2020
  end-page: 375
  article-title: Diagnostic accuracy of maternal serum multiple marker screening for early detection of gestational diabetes mellitus in the absence of a gold standard test
  publication-title: BMC Pregnancy Childbirth
– volume: 28
  start-page: 448
  year: 2014
  end-page: 459
  article-title: Gestational diabetes mellitus alters apoptotic and inflammatory gene expression of trophobasts from human term placenta
  publication-title: J Diabetes Complications
– volume: 52
  start-page: 1103
  year: 2015
  end-page: 1112
  article-title: Early second-trimester plasma protein profiling using multiplexed isobaric tandem mass tag (TMT) labeling predicts gestational diabetes mellitus
  publication-title: Acta Diabetol
– volume: 23
  start-page: 2325
  year: 2019
  end-page: 2331
  article-title: Effect of miR-29b on rats with gestational diabetes mellitus by targeting PI3K/Akt signal
  publication-title: Eur Rev Med Pharmacol Sci
– volume: 19
  start-page: 65
  year: 2020
  end-page: 65
  article-title: Autophagy-associated circRNA circCDYL augments autophagy and promotes breast cancer progression
  publication-title: Mol Cancer
– year: 2021
  article-title: Identification of differentially expressed circular RNAs associated with thymoma
  publication-title: Thorac Cancer
– volume: 357
  start-page: 275
  year: 2011
  end-page: 282
  article-title: Analysis of rpoS and bolA gene expression under various stress-induced environments in planktonic and biofilm phase using 2(-ΔΔCT) method
  publication-title: Mol Cell Biochem
– volume: 62
  start-page: 306
  year: 2019
  end-page: 310
  article-title: Gestational diabetes in young women predicts future risk of serious liver disease
  publication-title: Diabetologia
– volume: 18
  start-page: 51
  year: 2020
  end-page: 51
  article-title: Downregulation of hsa_circ_0005243 induces trophoblast cell dysfunction and inflammation via the β-catenin and NF-κB pathways
  publication-title: Reprod Biol Endocrinol
– volume: 10
  start-page: 2441
  year: 2014
  end-page: 2447
  article-title: KEGG-PATH: Kyoto encyclopedia of genes and genomes-based pathway analysis using a path analysis model
  publication-title: Mol Biosyst
– volume: 39
  start-page: 280
  year: 2020
  end-page: 280
  article-title: Circular RNA hsa_circ_0001829 promotes gastric cancer progression through miR-155-5p/SMAD2 axis
  publication-title: J Exp Clin Cancer Res
– volume: 418
  start-page: 41
  year: 2018
  end-page: 50
  article-title: Circular RNA: an emerging non-coding RNA as a regulator and biomarker in cancer
  publication-title: Cancer Lett
– volume: 21
  start-page: 5003
  year: 2020
  end-page: 5003
  article-title: Gestational diabetes mellitus: a harbinger of the vicious cycle of diabetes
  publication-title: Int J Mol Sci
– volume: 4
  start-page: 721
  year: 2007
  end-page: 726
  article-title: MicroRNA sponges: competitive inhibitors of small RNAs in mammalian cells
  publication-title: Nat Methods
– volume: 18
  start-page: 215
  year: 2020
  end-page: 229
  article-title: Circular RNAs: promising molecular biomarkers of human aging-related diseases via functioning as an miRNA sponge
  publication-title: Mol Ther Methods Clin Dev
– volume: 54
  start-page: 1691
  year: 2019
  end-page: 1703
  article-title: ZNF692 promotes colon adenocarcinoma cell growth and metastasis by activating the PI3K/AKT pathway
  publication-title: Int J Oncol
– volume: 20
  start-page: 265
  year: 2020
  end-page: 265
  article-title: The emerging roles of circular RNAs in ovarian cancer
  publication-title: Cancer Cell Int
– volume: 498
  start-page: 743
  year: 2018
  end-page: 750
  article-title: Circular RNA expression profiles in placental villi from women with gestational diabetes mellitus
  publication-title: Biochem Biophys Res Commun
– volume: 24
  start-page: 1609
  year: 2020
  end-page: 1615
  article-title: Effect of miR-26b on gestational diabetes mellitus in rats via PI3K/Akt signaling pathway
  publication-title: Eur Rev Med Pharmacol Sci
SSID ssj0025026
Score 2.3997135
Snippet Circular RNAs (circRNAs) has emerged as vital regulator involved in various diseases. In this study, we identified and investigated the potential circRNAs...
Background Circular RNAs (circRNAs) has emerged as vital regulator involved in various diseases. In this study, we identified and investigated the potential...
Abstract Background: Circular RNAs (circRNAs) has emerged as vital regulator involved in various diseases. In this study, we identified and investigated the...
Abstract Background Circular RNAs (circRNAs) has emerged as vital regulator involved in various diseases. In this study, we identified and investigated the...
SourceID doaj
scielo
pubmedcentral
proquest
gale
pubmed
crossref
SourceType Open Website
Open Access Repository
Aggregation Database
Index Database
Enrichment Source
StartPage 14
SubjectTerms Binding sites
BIOLOGY
Biomarkers
Cancer
Cell culture
Cell growth
Cell proliferation
Cell Proliferation - genetics
Cholesterol
circ_0008285
Circular RNA
Diabetes in pregnancy
Diabetes mellitus
Diabetes, Gestational - genetics
Female
Functional analysis
Gestational diabetes
Gestational diabetes mellitus
Glucose
Glycosylated hemoglobin
Hemoglobin
Humans
Low density lipoprotein
Low density lipoproteins
Medical research
Medicine, Experimental
MicroRNA
MicroRNAs
MicroRNAs - genetics
miRNA
Multiple births
Next-generation sequencing
Obesity
Plasma
Polymerase chain reaction
Pregnancy
Reagents
RNA, Circular
Therapeutic targets
Trophoblasts
Type 2 diabetes
Womens health
SummonAdditionalLinks – databaseName: DOAJ Directory of Open Access Journals
  dbid: DOA
  link: http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwrV1Lb9QwELZQVSQuiDeBFhmExAFFzdOP47aiKkj00FKpN8t2YrpSm1Sb7KEH_jsztrNsQIILhz3seqK1Pe94_A0h75mTFryATsG32bSyTKfaujo1vGXS8KwRDC84fz1lJxfVl8v6cqvVF9aEBXjgsHEHkMFoMKJ10eZNZXMhcitsxrmoGvz4bB183pRMxVSrhtRiuiIj2MFQ4fFhiuUI2LwM1Grmhjxa_582ecsp_V4wuYv-6XrbFR0_Ig9jDEkXYe6Pyb22e0Luh66Sd0_JD2A9xapB2jtqlytfaUrPThf-i8oCnhxddhTPluLLQDq9hKU3CNE5rgdq7ugqdKoH90YhUKQBsQnZStEfepHFPxlX_e1VbyAQH4dn5OL407ejkzR2WUgtK9mYagYqWUiLsYx1aDhlkzkBYZIoW-M4r11unTZVCwmn0VpCitM40eTagD6DwXhOdrq-a18SWpu8KaTLCtNC4iU0EBZGmMJKCAuAVwnJp01XNkKQYyeMa-VTEcFUYJQCRinPKFUm5OPmmdsAwPFX6kPk5YYSwbP9DyBSKoqU-pdIJeQdSoJCeIwO62--6_UwqM_nZ2qB4QysTbKEfIhEroc1WB2vM8BOIKLWjHJvRgn6a-fDk8CpaD8GBZMTQjKR8YS83Qzjk1gT17X9GmlyBsEdL0VCXgT53Ky7LAVHJMiE8JnkzjZmPtItrzy6uMjwJFzC-oKM_5rUOYSjTEH8CilGgedCuUfce_U_9vw1eVB49azAbu-RnXG1bvch3BvNG6_ZPwFDaku0
  priority: 102
  providerName: Directory of Open Access Journals
– databaseName: Health & Medical Collection
  dbid: 7X7
  link: http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwfV1Lb9QwELaggMQF8SZQkEFIHFDUxEls54QWRFWQ6KGl0t4s24nblUqyJNlDD_x3ZhxntwGpx40n2tiet8ffEPKeu9KCFdAx2DYb55brWFtXxEbUvDQiqSTHC84_jvnRWf59WSxDwq0PZZWTTvSKumot5sgPWMGkLLlMxKf17xi7RuHpamihcZvcQegy5Gqx3AVcReLbrYEV5TGY3WS6NCP5QZ_jgWKMBQrYzgwEbWaYPH7__1r6mpn6t4TyLlqsy-vG6fAheRC8SroY2eARuVU3j8m9sc_k1RPyB5iBYh0hbR21q87XntKT44X_oZIRYY6uGoqnTSE9SKe0LP2FoJ3DpqfminZj73oweBRcRzpiOOFGU7SQnonxT4auXV-0BlzzoX9Kzg6__vxyFIe-C7HlGR9izUFIWWnRu7EOVWlZJU6C4ySz2jghCpdap01eQwhqtC4h6KmcrFJtQMJBhTwje03b1C8ILUxasdIlzNQQikkNhMxIw2wJjkJeJRFJp0VXNoCSY2-MS-WDE8nVuFEKNkr5jVJZRD5u31mPkBw3Un_GvdxSIpy2f9B25ypIp4IwWYOlLlidVrlNpUyttIkQ8Ili_Mx3yAkKATMarMg515u-V99OT9QCHRyYW8kj8iEQuRbmYHW44AArgRhbM8r9GSVItJ0PTwyngkbp1Y7_I_J2O4xvYpVcU7cbpEk5uHsikxF5PvLndt5ZJgViQ0ZEzDh3tjDzkWZ14fHGZYJn4yXMb-Tx3UedomgpFC2GuQNMMCAG38ubJ_CK3Gde8HLQ0ftkb-g29Wtw7QbzxsvvX_LlRp4
  priority: 102
  providerName: ProQuest
Title The role of circular RNA circ_0008285 in gestational diabetes mellitus by regulating the biological functions of trophoblasts
URI https://www.ncbi.nlm.nih.gov/pubmed/33879262
https://www.proquest.com/docview/2528896807
https://www.proquest.com/docview/2516223738
https://pubmed.ncbi.nlm.nih.gov/PMC8056579
http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602021000100214&lng=en&tlng=en
https://doaj.org/article/825a01252e1d4c1881c8c07784d784d0
Volume 54
hasFullText 1
inHoldings 1
isFullTextHit
isPrint
link http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwjV1Lj9MwELb2ARIXxJvAUhmExAEF8rSdA0JdtKul0laopVJvlu0ku5VKsiSpRA_8d2acpGxghThVrSeNHzOeGc_4G0JeszwxoAWUC7rNuJFhylUmj13NM5Zo7qWC4QXn8yk7W0STZbzcI325o24C6xtdO6wntajW7358334Egf9gBV6w93WEwUEXkw2wNBkIzT45BM3EsaLBebSLKoC2t-XX0IVxGbgK_SWaG_9joKgsnv_fu_Y1tfVnSuUt1GDr68rq9B6521mZdNyyxX2ylxUPyO227uT2IfkJzEExr5CWOTWryuai0tl0bL9Ir0Wco6uCYvSpOy6k_TEt_YYgns2mpnpLq7aWPShACqYkbTGdcOEpakzL1PiSpiqvLksNpnpTPyKL05Ovn87crg6Da1jIGlcxENogMWjtmBy31iT1cgGGlAgznXMe577JlY4ycEm1Ugk4QWkuUl9pkHjYUh6Tg6IssqeExtpPgyT3Ap2BayYUEAZa6MAkYDhEqecQv590aTqQcqyVsZbWWRFMtgslYaGkXSgZOuTt7pmrFqLjn9THuJY7SoTXtj-U1YXspFWC26xAc8dB5qeR8YXwjTAe59BF3nbzFXKCRACNAjN0LtSmruXn-UyO0eCBsSXMIW86oryEMRjVXXiAmUDMrQHl0YASJNwMm3uGk72ASOicEAkTHnfIy10zPolZc0VWbpDGZ2D-8VA45EnLn7txh6HgiBXpED7g3MHEDFuK1aXFHxcexsoTGF_L4787NQfRYhIsXHBCAowc-RaT79l_z8RzciewMhjB9n1EDppqk70Aq6_RI7LPl3xEDsfjyXwCn8cn0y-zkT1DGVkx_wXOWlLU
linkProvider Scholars Portal
linkToHtml http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwtV1Lj9MwELaWBQQXxJvAAgaBOKBo87SdA0LlsWrZ3R72IfVmbCfpVlqS0qRCPfCX-I3MOEm7AWlve2wzaW3P45uxxzOEvGF5YgAFlAvYZtzIMOUqk8eu5hlLNPdSwfCC8-GYDU-jb5N4skX-dHdhMK2ys4nWUKelwT3y3SAOhEiY8PjH-U8Xu0bh6WrXQqMRi_1s9QtCturD6Avw920Q7H09-Tx0264CrmEhq13FQASDxCB2mxwNRZJ6uQC3QISZzjmPc9_kSkcZBFhaqQRc-jQXqa80yC8oCPzuNXIdgNfDYI9PNgFe7Nn2boDazAWY97pLOoLtVhEeYLqYEIHt00Cxe0Bo-wX8jwoXYPHflM0biJDnF8Fw7y6503qxdNCI3T2ylRX3yc2mr-XqAfkNwkcxb5GWOTWzhc11pUfjgf0gvaaiHZ0VFE-32u1I2m0D0x9YJLReVlSv6CKb2gZjxZSCq0qbmlEoWBQR2SoN_km9KOdnpYZQoK4ektMr4cgjsl2URfaE0Fj7aZDkXqAzCP2EAsJACx2YBByTKPUc4neLLk1bBB17cZxLGwwJJhtGSWCUtIySoUPer9-ZNyVALqX-hLxcU2L5bvtFuZjK1hpICMsVeAZxkPlpZHwhfCOMxzkMkTfDfI2SILFAR4EZQFO1rCo5Oj6SA3SoYG4Jc8i7ligvYQ5GtRcqYCWwplePcqdHCRbE9B93AidbC1bJjb455NX6Mb6JWXlFVi6RxmfgXvJQOORxI5_reYeh4FiL0iG8J7m9hek_KWZntr658PAsPoH5NTK-GdQxqpZE1QpwrwI3NLDm39PLJ_CS3BqeHB7Ig9F4_xm5HVgljAAfdsh2vVhmz8GtrPULq8uUfL9q4_EXoqKDEQ
openUrl ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=The+role+of+circular+RNA+circ_0008285+in+gestational+diabetes+mellitus+by+regulating+the+biological+functions+of+trophoblasts&rft.jtitle=Biological+research&rft.au=Chen%2C+Haitian&rft.au=Zhang%2C+Shaofeng&rft.au=Wu%2C+Yanxin&rft.au=Li%2C+Zhuyu&rft.date=2021-04-20&rft.pub=BioMed+Central+Ltd&rft.issn=0717-6287&rft.volume=54&rft.issue=1&rft_id=info:doi/10.1186%2Fs40659-021-00337-3&rft.externalDocID=A661414996
thumbnail_l http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=0717-6287&client=summon
thumbnail_m http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=0717-6287&client=summon
thumbnail_s http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=0717-6287&client=summon