3,5-Nonadiyne Isolated from the Rhizome of Cachrys ferulacea Inhibits Endogenous Nitric Oxide Release by Rat Peritoneal Macrophages

• Published in: Chemical & Pharmaceutical Bulletin Vol. 52; no. 7; pp. 853 - 854
• Main Authors: Đoković, Dejan D., Bulatović, Vanja M., Božić, Biljana Đ., Kataranovski, Milena V., Zrakić, Tomislav M., Kovačević, Nada N.
• Format: Journal Article
• Language: English; Japanese
• Published: TOKYO The Pharmaceutical Society of Japan 2004; Pharmaceutical Society of Japan; Pharmaceutical Soc Japan; Japan Science and Technology Agency
• Subjects: 3,5-nonadiyne; Alkynes - chemistry; Alkynes - isolation & purification; Alkynes - pharmacology; Animals; Apiaceae; Cachrys ferulacea; Chemistry; Chemistry, Medicinal; Chemistry, Multidisciplinary; endogenous nitric oxide; inhibition; Life Sciences & Biomedicine; Macrophages, Peritoneal - drug effects; Macrophages, Peritoneal - metabolism; Male; Nitric Oxide - antagonists & inhibitors; Nitric Oxide - metabolism; Oils, Volatile - isolation & purification; Oils, Volatile - pharmacology; Pharmacology & Pharmacy; Physical Sciences; Plant Roots; Prangos ferulacea; Rats; Rhizome; Science & Technology; Cachrys ferulacea; inhibition; 3,5-nonadiyne; Prangos ferulacea; endogenous nitric oxide
• ISSN: 0009-2363; 1347-5223
• DOI: 10.1248/cpb.52.853

3,5-Nonadiyne, in vitro, selectively inhibits endogenous nitric oxide release (IC50=6.7±0.8 μM) by rat peritoneal macrophages at doses that do not inhibit T cell proliferation. 3,5-Nonadiyne was isolated from root essential oil of Cachrys ferulacea (L.) CALESTANI, synonym Prangos ferulacea (L.) LINDLEY, obtained by hydrodistillation and spectrometricaly identified unambiguously.