Cytotoxic Allyl Retrochalcone from the Roots of Glycyrrhiza inflata

Two known retrochalcones, licochalcone A (1) and licochalcone C (2), and one new retrochalcone, licochalcone E (4) were isolated by cytotoxicity-guided fractionation from the roots of Glycyrrhiza inflata along with an ordinary chalcone, isoliquiritigenin (3). The structure of the new retrochalcone w...

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Bibliographic Details
Published inChemical & Pharmaceutical Bulletin Vol. 53; no. 6; pp. 694 - 695
Main Authors Yoon, Goo, Jung, Young Do, Cheon, Seung Hoon
Format Journal Article
LanguageEnglish
Published TOKYO The Pharmaceutical Society of Japan 2005
Pharmaceutical Society of Japan
Pharmaceutical Soc Japan
Japan Science and Technology Agency
Subjects
Cell Line, Tumor
Chalcones - chemistry
Chalcones - isolation & purification
Chalcones - toxicity
Chemistry
Chemistry, Medicinal
Chemistry, Multidisciplinary
cytotoxicity
Cytotoxins - chemistry
Cytotoxins - isolation & purification
Cytotoxins - toxicity
Glycyrrhiza - toxicity
Glycyrrhiza inflata
Humans
licochalcone E
Life Sciences & Biomedicine
Pharmacology & Pharmacy
Physical Sciences
Plant Roots
retrochalcone
Science & Technology
licochalcone E
retrochalcone
Glycyrrhiza inflata
ISOLIQUIRITIGENIN
LICOCHALCONE-A
FLAVONOIDS
cytotoxicity
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Summary:Two known retrochalcones, licochalcone A (1) and licochalcone C (2), and one new retrochalcone, licochalcone E (4) were isolated by cytotoxicity-guided fractionation from the roots of Glycyrrhiza inflata along with an ordinary chalcone, isoliquiritigenin (3). The structure of the new retrochalcone was elucidated through a spectroscopic analysis.
ISSN:0009-2363
1347-5223
DOI:10.1248/cpb.53.694