Major Metabolites of Ginseng Sapogenins formed by Rat Liver Microsomes

Incubation of ginseng sapogenins with microsomes from rat liver resulted in formation of their 20, 24-epoxides as major metabolites. Identification of the metabolites was performed by HPLC, FAB-MS and EI-MS.

Saved in:
Bibliographic Details
Published inChemical & pharmaceutical bulletin Vol. 48; no. 8; pp. 1226 - 1227
Main Authors KASAI, Ryoji, HARA, Kazumasa, DOKAN, Rumiko, SUZUKI, Noriko, MIZUTARE, Tohru, YOSHIHARA, Shin'ichi, YAMASAKI, Kazuo
Format Journal Article
LanguageEnglish
Published Tokyo The Pharmaceutical Society of Japan 01.08.2000
Maruzen
Japan Science and Technology Agency
Subjects
20(S)-protopanaxadiol
20(S)-protopanaxadiol oxide
20(S)-protopanaxatriol
20(S)-protopanaxatriol oxide
Animals
Biological and medical sciences
Biotransformation
Chromatography, High Pressure Liquid
General pharmacology
ginsenoside
Medical sciences
microsomal metabolite
Microsomes, Liver - metabolism
Panax - metabolism
Pharmacognosy. Homeopathy. Health food
Pharmacology. Drug treatments
Plants, Medicinal
Rats
Sapogenins - metabolism
Asia
China
Steroid
Terpenoid
Rat
Pharmacognosy
Rodentia
Sapogenin
Metabolism
In vitro
Panax ginseng
Medicinal plant
Vertebrata
Mammalia
Folk medicine
Dicotyledones
Animal
Angiospermae
Epoxide
Triterpene
S configuration
Spermatophyta
Pharmacokinetics
Araliaceae
Online AccessGet full text

Cover

More Information
Summary:Incubation of ginseng sapogenins with microsomes from rat liver resulted in formation of their 20, 24-epoxides as major metabolites. Identification of the metabolites was performed by HPLC, FAB-MS and EI-MS.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:0009-2363
1347-5223
DOI:10.1248/cpb.48.1226