Pregnane xenobiotic receptor in cancer pathogenesis and therapeutic response

• Published in: Cancer letters Vol. 328; no. 1; pp. 1 - 9
• Main Authors: Pondugula, Satyanarayana R, Mani, Sridhar
• Format: Journal Article
• Language: English
• Published: Ireland Elsevier Ireland Ltd 01.01.2013; Elsevier Limited
• Subjects: animal ovaries; antineoplastic agents; Antineoplastic Agents - therapeutic use; apoptosis; Breast cancer; Cancer; Cell growth; Dog; Drug Resistance; Endocrine disruption; endocrine-disrupting chemicals; endometrium; enzymes; Estrogens; gene expression regulation; genes; Hematology, Oncology and Palliative Medicine; Humans; liver; Medical research; metabolism; metastasis; Neoplasms - drug therapy; Neoplasms - pathology; pathogenesis; prognosis; PXR; Receptors, Steroid - metabolism; transporters; Treatment Outcome; xenobiotics; Xenobiotics - metabolism; Endocrine disruption; PXR; Drug resistance; Dog; Cancer

Highlights ► PXR is an orphan nuclear receptor that is activated by both endobiotics and xenobiotics, including anticancer drugs. ► PXR has been implicated in chemoresistance and in tumor growth, promotion, and metastasis. ► PXR has been proposed as a therapeutic target in treating cancers. ► Identi...