Pregnane xenobiotic receptor in cancer pathogenesis and therapeutic response

Highlights ► PXR is an orphan nuclear receptor that is activated by both endobiotics and xenobiotics, including anticancer drugs. ► PXR has been implicated in chemoresistance and in tumor growth, promotion, and metastasis. ► PXR has been proposed as a therapeutic target in treating cancers. ► Identi...

Full description

Saved in:
Bibliographic Details
Published inCancer letters Vol. 328; no. 1; pp. 1 - 9
Main Authors Pondugula, Satyanarayana R, Mani, Sridhar
Format Journal Article
LanguageEnglish
Published Ireland Elsevier Ireland Ltd 01.01.2013
Elsevier Limited
Subjects
animal ovaries
antineoplastic agents
Antineoplastic Agents - therapeutic use
apoptosis
Breast cancer
Cancer
Cell growth
Dog
Drug Resistance
Endocrine disruption
endocrine-disrupting chemicals
endometrium
enzymes
Estrogens
gene expression regulation
genes
Hematology, Oncology and Palliative Medicine
Humans
liver
Medical research
metabolism
metastasis
Neoplasms - drug therapy
Neoplasms - pathology
pathogenesis
prognosis
PXR
Receptors, Steroid - metabolism
transporters
Treatment Outcome
xenobiotics
Xenobiotics - metabolism
Endocrine disruption
PXR
Drug resistance
Dog
Cancer
Online AccessGet full text

Cover

More Information
Summary:Highlights ► PXR is an orphan nuclear receptor that is activated by both endobiotics and xenobiotics, including anticancer drugs. ► PXR has been implicated in chemoresistance and in tumor growth, promotion, and metastasis. ► PXR has been proposed as a therapeutic target in treating cancers. ► Identification of novel selective PXR modulators, particularly antagonists, would be beneficial to improve the therapeutic outcomes of PXR expressing cancers.
Bibliography:http://dx.doi.org/10.1016/j.canlet.2012.08.030
ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-3
content type line 23
ObjectType-Review-1
ISSN:0304-3835
1872-7980
DOI:10.1016/j.canlet.2012.08.030