Gastric cancer stem cells: A novel therapeutic target

Highlights • Gastric cancer is one of the leading causes of global cancer mortality. • Several environmental and genetic factors promote gastric cancer. • Gastric stem cells play an import role in the self-renewal and homeostasis of the gastric gland. • Gastric cancer originates from normal resident...

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Bibliographic Details
Published inCancer letters Vol. 338; no. 1; pp. 110 - 119
Main Author Singh, Shree Ram
Format Journal Article
LanguageEnglish
Published Ireland Elsevier Ireland Ltd 10.09.2013
Elsevier Limited
Subjects
Antineoplastic Agents - therapeutic use
Cancer stem cells
Cancer therapies
Cell Transformation, Neoplastic - drug effects
Cell Transformation, Neoplastic - pathology
Gastric cancer
Gastric epithelial cells
gastric mucosa
Gastric Mucosa - drug effects
Gastric Mucosa - pathology
Hematology, Oncology and Palliative Medicine
Homeostasis
Humans
in vivo studies
Medical research
Metastasis
mice
Models, Biological
Mortality
Mutation
Neoplastic Stem Cells - drug effects
Neoplastic Stem Cells - pathology
Patients
Stem Cell Niche - drug effects
Stem cells
Stomach
stomach neoplasms
Stomach Neoplasms - drug therapy
Stomach Neoplasms - pathology
Tumor Microenvironment - drug effects
Tumors
United States > US
Stomach
Gastric epithelial cells
Cancer stem cells
Gastric cancer
Stem cells
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Summary:Highlights • Gastric cancer is one of the leading causes of global cancer mortality. • Several environmental and genetic factors promote gastric cancer. • Gastric stem cells play an import role in the self-renewal and homeostasis of the gastric gland. • Gastric cancer originates from normal resident stem cells or bone marrow-derived cells. • Targeting gastric cancer stem cells would be novel therapeutic strategies to cure gastric cancer.
Bibliography:http://dx.doi.org/10.1016/j.canlet.2013.03.035
ISSN:0304-3835
1872-7980
DOI:10.1016/j.canlet.2013.03.035