Shape-Dependent Targeting of Injured Blood Vessels by Peptide Amphiphile Supramolecular Nanostructures

• Published in: Small (Weinheim an der Bergstrasse, Germany) Vol. 11; no. 23; pp. 2750 - 2755
• Main Authors: Moyer, Tyson J., Kassam, Hussein A., Bahnson, Edward S. M., Morgan, Courtney E., Tantakitti, Faifan, Chew, Teng L., Kibbe, Melina R., Stupp, Samuel I.
• Format: Journal Article
• Language: English
• Published: Germany Blackwell Publishing Ltd 01.06.2015; Wiley Subscription Services, Inc
• Subjects: Animals; Binding; Blood vessels; Carotid Artery Injuries - drug therapy; Carotid Artery Injuries - pathology; Equivalence; Injuries; Macromolecular Substances; Male; Nanofibers; Nanoparticles - administration & dosage; Nanoparticles - chemistry; Nanostructure; Nanotechnology; Particle Size; Peptides; Peptides - administration & dosage; Peptides - chemistry; Rats; Rats, Sprague-Dawley; self-assembly; supramolecular chemistry; Surface-Active Agents - administration & dosage; Surface-Active Agents - chemistry; Tracking; Treatment Outcome; vascular targeting; self-assembly; peptides; vascular targeting; supramolecular chemistry
• ISSN: 1613-6810; 1613-6829
• DOI: 10.1002/smll.201403429

Targeting of vascular intervention by systemically delivered supramolecular nanofibers after balloon angioplasty is described. Tracking of self‐assembling peptide amphiphiles using fluorescence shows selective binding to the site of vascular intervention. Cylindrical nanostructures are observed to target the site of arterial injury, while spherical nanostructures with an equivalent diameter display no binding.