Recent Advances in Transition Metal-Catalyzed Methylation Reactions
Methylation is one of the most fundamental synthetic transformations in organic chemistry, but usually employs hazardous and toxic reagents, such as methyl iodide, dimethyl sulfate, diazomethane and dimethyl carbonate. In order to address sustainable development and green strategies, synthetic chemi...
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Published in | Advanced synthesis & catalysis Vol. 357; no. 7; pp. 1333 - 1350 |
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Main Authors | , , , |
Format | Journal Article |
Language | English |
Published |
Weinheim
WILEY-VCH Verlag
04.05.2015
WILEY‐VCH Verlag |
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Abstract | Methylation is one of the most fundamental synthetic transformations in organic chemistry, but usually employs hazardous and toxic reagents, such as methyl iodide, dimethyl sulfate, diazomethane and dimethyl carbonate. In order to address sustainable development and green strategies, synthetic chemists have devoted much effort to the discovery and development of new methylating reagents, which are successfully being applied in transition metal‐catalyzed cross‐coupling reactions. In this review, recent advances in this area are summarized, mainly including C‐methylation, N‐methylation and O‐methylation. The respective reaction mechanisms are also discussed. |
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AbstractList | Methylation is one of the most fundamental synthetic transformations in organic chemistry, but usually employs hazardous and toxic reagents, such as methyl iodide, dimethyl sulfate, diazomethane and dimethyl carbonate. In order to address sustainable development and green strategies, synthetic chemists have devoted much effort to the discovery and development of new methylating reagents, which are successfully being applied in transition metal‐catalyzed cross‐coupling reactions. In this review, recent advances in this area are summarized, mainly including
C
‐methylation,
N
‐methylation and
O
‐methylation. The respective reaction mechanisms are also discussed.
magnified image Methylation is one of the most fundamental synthetic transformations in organic chemistry, but usually employs hazardous and toxic reagents, such as methyl iodide, dimethyl sulfate, diazomethane and dimethyl carbonate. In order to address sustainable development and green strategies, synthetic chemists have devoted much effort to the discovery and development of new methylating reagents, which are successfully being applied in transition metal-catalyzed cross-coupling reactions. In this review, recent advances in this area are summarized, mainly including C-methylation, N-methylation and O-methylation. The respective reaction mechanisms are also discussed. |
Author | Borah, Arun Jyoti Yang, Minghua Wang, Lianggui Yan, Guobing |
Author_xml | – sequence: 1 givenname: Guobing surname: Yan fullname: Yan, Guobing email: gbyan@lsu.edu.cn organization: Department of Chemistry, Lishui University, No. 1, Xueyuan Road, Lishui City 323000, People's Republic of China, Fax: (+86)-578-2271-250; phone: (+86)-578-2271-250 – sequence: 2 givenname: Arun Jyoti surname: Borah fullname: Borah, Arun Jyoti organization: Department of Chemistry, Lishui University, No. 1, Xueyuan Road, Lishui City 323000, People's Republic of China, Fax: (+86)-578-2271-250; phone: (+86)-578-2271-250 – sequence: 3 givenname: Lianggui surname: Wang fullname: Wang, Lianggui organization: Department of Chemistry, Lishui University, No. 1, Xueyuan Road, Lishui City 323000, People's Republic of China, Fax: (+86)-578-2271-250; phone: (+86)-578-2271-250 – sequence: 4 givenname: Minghua surname: Yang fullname: Yang, Minghua organization: Department of Chemistry, Lishui University, No. 1, Xueyuan Road, Lishui City 323000, People's Republic of China, Fax: (+86)-578-2271-250; phone: (+86)-578-2271-250 |
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Snippet | Methylation is one of the most fundamental synthetic transformations in organic chemistry, but usually employs hazardous and toxic reagents, such as methyl... |
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SubjectTerms | Carbonates Chemists cross-coupling Dimethyl Iodides Methylation Strategy Sustainable development Transformations transition metal catalysts |
Title | Recent Advances in Transition Metal-Catalyzed Methylation Reactions |
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