Recent Advances in Transition Metal-Catalyzed Methylation Reactions

Methylation is one of the most fundamental synthetic transformations in organic chemistry, but usually employs hazardous and toxic reagents, such as methyl iodide, dimethyl sulfate, diazomethane and dimethyl carbonate. In order to address sustainable development and green strategies, synthetic chemi...

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Published inAdvanced synthesis & catalysis Vol. 357; no. 7; pp. 1333 - 1350
Main Authors Yan, Guobing, Borah, Arun Jyoti, Wang, Lianggui, Yang, Minghua
Format Journal Article
LanguageEnglish
Published Weinheim WILEY-VCH Verlag 04.05.2015
WILEY‐VCH Verlag
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Abstract Methylation is one of the most fundamental synthetic transformations in organic chemistry, but usually employs hazardous and toxic reagents, such as methyl iodide, dimethyl sulfate, diazomethane and dimethyl carbonate. In order to address sustainable development and green strategies, synthetic chemists have devoted much effort to the discovery and development of new methylating reagents, which are successfully being applied in transition metal‐catalyzed cross‐coupling reactions. In this review, recent advances in this area are summarized, mainly including C‐methylation, N‐methylation and O‐methylation. The respective reaction mechanisms are also discussed.
AbstractList Methylation is one of the most fundamental synthetic transformations in organic chemistry, but usually employs hazardous and toxic reagents, such as methyl iodide, dimethyl sulfate, diazomethane and dimethyl carbonate. In order to address sustainable development and green strategies, synthetic chemists have devoted much effort to the discovery and development of new methylating reagents, which are successfully being applied in transition metal‐catalyzed cross‐coupling reactions. In this review, recent advances in this area are summarized, mainly including C ‐methylation, N ‐methylation and O ‐methylation. The respective reaction mechanisms are also discussed. magnified image
Methylation is one of the most fundamental synthetic transformations in organic chemistry, but usually employs hazardous and toxic reagents, such as methyl iodide, dimethyl sulfate, diazomethane and dimethyl carbonate. In order to address sustainable development and green strategies, synthetic chemists have devoted much effort to the discovery and development of new methylating reagents, which are successfully being applied in transition metal-catalyzed cross-coupling reactions. In this review, recent advances in this area are summarized, mainly including C-methylation, N-methylation and O-methylation. The respective reaction mechanisms are also discussed.
Author Borah, Arun Jyoti
Yang, Minghua
Wang, Lianggui
Yan, Guobing
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  organization: Department of Chemistry, Lishui University, No. 1, Xueyuan Road, Lishui City 323000, People's Republic of China, Fax: (+86)-578-2271-250; phone: (+86)-578-2271-250
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  surname: Borah
  fullname: Borah, Arun Jyoti
  organization: Department of Chemistry, Lishui University, No. 1, Xueyuan Road, Lishui City 323000, People's Republic of China, Fax: (+86)-578-2271-250; phone: (+86)-578-2271-250
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  givenname: Lianggui
  surname: Wang
  fullname: Wang, Lianggui
  organization: Department of Chemistry, Lishui University, No. 1, Xueyuan Road, Lishui City 323000, People's Republic of China, Fax: (+86)-578-2271-250; phone: (+86)-578-2271-250
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  givenname: Minghua
  surname: Yang
  fullname: Yang, Minghua
  organization: Department of Chemistry, Lishui University, No. 1, Xueyuan Road, Lishui City 323000, People's Republic of China, Fax: (+86)-578-2271-250; phone: (+86)-578-2271-250
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2007; 107
2014; 70
1963; 43
2013; 4
2000; 41
2014 2014; 126 53
2011; 13
2007; 72
2011 2011; 123 50
2011; 111
2001; 42
2014; 20
2009; 11
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1995; 60
2013; 15
2014; 5
2013; 11
2000
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2014; 16
2007; 9
2003; 5
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2003; 125
2014; 50
2006; 128
2003; 44
2005 2005; 117 44
1965; 30
1995; 51
1995; 95
1997; 62
2007; 129
2004; 104
2013; 46
1984; 106
2004; 45
2011; 40
2013; 42
2013 2013; 125 52
2006; 8
1997
1996
1995
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2011; 76
2005
2004
2009; 131
2001; 66
1996; 10
2014; 356
2011; 133
2009; 28
2010; 43
1998; 39
2012; 112
2012; 354
2013; 78
2002; 67
2003; 68
2010; 132
2005; 7
2013; 135
2014; 79
2001; 3
2009; 7
2008; 41
2012; 45
2012; 44
2006; 348
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Snippet Methylation is one of the most fundamental synthetic transformations in organic chemistry, but usually employs hazardous and toxic reagents, such as methyl...
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SubjectTerms Carbonates
Chemists
cross-coupling
Dimethyl
Iodides
Methylation
Strategy
Sustainable development
Transformations
transition metal catalysts
Title Recent Advances in Transition Metal-Catalyzed Methylation Reactions
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