Recent Advances in Transition Metal-Catalyzed Methylation Reactions

Methylation is one of the most fundamental synthetic transformations in organic chemistry, but usually employs hazardous and toxic reagents, such as methyl iodide, dimethyl sulfate, diazomethane and dimethyl carbonate. In order to address sustainable development and green strategies, synthetic chemi...

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Published inAdvanced synthesis & catalysis Vol. 357; no. 7; pp. 1333 - 1350
Main Authors Yan, Guobing, Borah, Arun Jyoti, Wang, Lianggui, Yang, Minghua
Format Journal Article
LanguageEnglish
Published Weinheim WILEY-VCH Verlag 04.05.2015
WILEY‐VCH Verlag
Subjects
Carbonates
Chemists
cross-coupling
Dimethyl
Iodides
Methylation
Strategy
Sustainable development
Transformations
transition metal catalysts
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Summary:Methylation is one of the most fundamental synthetic transformations in organic chemistry, but usually employs hazardous and toxic reagents, such as methyl iodide, dimethyl sulfate, diazomethane and dimethyl carbonate. In order to address sustainable development and green strategies, synthetic chemists have devoted much effort to the discovery and development of new methylating reagents, which are successfully being applied in transition metal‐catalyzed cross‐coupling reactions. In this review, recent advances in this area are summarized, mainly including C‐methylation, N‐methylation and O‐methylation. The respective reaction mechanisms are also discussed.
Bibliography:Natural Science Foundation of Zhejiang Province - No. LY12B02006
ArticleID:ADSC201400984
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ISSN:1615-4150
1615-4169
DOI:10.1002/adsc.201400984