Plasma B-type natriuretic peptide in predicting outcomes of elective coronary artery bypass surgery

• Published in: The Kaohsiung journal of medical sciences Vol. 29; no. 5; pp. 254 - 258
• Main Authors: Chen, Thay-Hsiung, Lin, Ching-Ling, Shih, Joseph Jaey-Ming, Shih, James Yao-Ming, Chen, Chung-Huo, Chang, Mei-Ling, Chin, Chih-Hui
• Format: Journal Article
• Language: English
• Published: China (Republic : 1949- ) Elsevier B.V 01.05.2013; John Wiley & Sons, Inc; Wiley
• Subjects: Aged; B-type natriuretic peptide; Biomarkers - blood; Coronary Artery Bypass; Coronary artery bypass surgery; Coronary Artery Disease - blood; Coronary Artery Disease - surgery; Coronary heart disease; Elective Surgical Procedures; Ethylenediaminetetraacetic acid; Female; Humans; Internal Medicine; Length of Stay; Male; Medical research; Medicine, Experimental; Middle Aged; Multivariate Analysis; Natriuretic Peptide, Brain - blood; Natriuretic peptides; Patient outcomes; Prognosis; Prolonged hospital stay; Prospective Studies; Protein Precursors - blood; Risk Factors; Surgery; Treatment Outcome; Coronary artery bypass surgery; Prolonged hospital stay; B-type natriuretic peptide
• ISSN: 1607-551X; 2410-8650
• DOI: 10.1016/j.kjms.2012.09.003

Abstract The risks of surgery and its clinical outcome are of great importance for both patients and physicians when choosing coronary artery bypass (CABG) surgery for coronary artery disease. The purpose of the current study was to clarify the relationship between serum B-type natriuretic peptide (BNP) and patient clinical outcome. Seventy-six eligible patients who underwent CABG were enrolled into the prospective study. Venous blood samples were drawn for serum BNP and N-terminal (NT)-proBNP levels measurement on preoperative Day 1, postoperative Day 1, and postoperative Day 7. Clinical end points were: (1) intensive care unit (ICU) stay longer than 4 days postoperatively and/or hospital stay longer than 13 days postoperatively; (2) major complications and poor outcomes. Patients who had prolonged ICU stay and hospitalization had significantly higher postoperative Day 1 BNP and postoperative Day 1 NT-proBNP level ( p  = 0.02 and 0.005, respectively). Age was significantly older in patients with prolonged ICU stay and hospitalization than those without prolonged ICU stay and hospitalization ( p  = 0.03). Serum creatinine level was also significantly increased in patients with prolonged ICU stay and hospitalization ( p  = 0.009). However, age was the only remaining factor that correlated with prolonged ICU stay and hospitalization in the multivariate logistic regression model. These results suggest that research using BNP and NT-proBNP for predicting ICU stay and hospitalization in patients who have undergone CABG must adjust risk factors to present a more appropriate estimation of its clinical outcome.