Association between 1,5-Anhydroglucitol and Acute C Peptide Response to Arginine among Patients with Type 2 Diabetes
Objective. The aim of this study was to explore the association of 1,5-anhydroglucitol with acute C peptide response (ACPR) to arginine among patients with type 2 diabetes. Methods. Patients with type 2 diabetes were enrolled from the Department of Endocrinology and Metabolism, Shanghai Sixth People...
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Published in | Journal of Diabetes Research Vol. 2020; no. 2020; pp. 1 - 7 |
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Main Authors | , , , , , , , , , , |
Format | Journal Article |
Language | English |
Published |
Cairo, Egypt
Hindawi Publishing Corporation
2020
Hindawi Hindawi Limited Wiley |
Subjects | |
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Abstract | Objective. The aim of this study was to explore the association of 1,5-anhydroglucitol with acute C peptide response (ACPR) to arginine among patients with type 2 diabetes. Methods. Patients with type 2 diabetes were enrolled from the Department of Endocrinology and Metabolism, Shanghai Sixth People’s Hospital. ACPR was assessed using arginine stimulation test. Decreased β-cell function was defined as ACPR<2.1. Multivariable logistic regression models were used to demonstrate the association between 1,5-anhydroglucitol and decreased β-cell function. Results. Finally, 623 patients with type 2 diabetes were enrolled into the analysis. Multivariable-adjusted odds ratios for decreased β-cell function across quartiles of 1,5-anhydroglucitol were 1.00, 0.47 (95% confidence interval (CI) 0.23-0.99), 0.41 (95% CI 0.20-0.84), and 0.27 (95% CI 0.13-0.57) (Ptrend=0.042), respectively. When 1,5-anhydroglucitol was considered as a continuous variable after logarithm, the corresponding odds ratio was 0.40 (95% CI 0.23-0.71). Conclusions. We demonstrated a dose-response linear association between 1,5-anhydroglucitol and ACPR. 1,5-Anhydroglucitol was likely to be associated with β-cell function. Further analysis with large sample size and prospective study design is warranted to validate our findings. |
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AbstractList | Objective
. The aim of this study was to explore the association of 1,5-anhydroglucitol with acute C peptide response (ACPR) to arginine among patients with type 2 diabetes.
Methods
. Patients with type 2 diabetes were enrolled from the Department of Endocrinology and Metabolism, Shanghai Sixth People’s Hospital. ACPR was assessed using arginine stimulation test. Decreased
β
-cell function was defined as
ACPR
<
2.1
. Multivariable logistic regression models were used to demonstrate the association between 1,5-anhydroglucitol and decreased
β
-cell function.
Results
. Finally, 623 patients with type 2 diabetes were enrolled into the analysis. Multivariable-adjusted odds ratios for decreased
β
-cell function across quartiles of 1,5-anhydroglucitol were 1.00, 0.47 (95% confidence interval (CI) 0.23-0.99), 0.41 (95% CI 0.20-0.84), and 0.27 (95% CI 0.13-0.57) (
P
trend
=
0.042
), respectively. When 1,5-anhydroglucitol was considered as a continuous variable after logarithm, the corresponding odds ratio was 0.40 (95% CI 0.23-0.71).
Conclusions
. We demonstrated a dose-response linear association between 1,5-anhydroglucitol and ACPR. 1,5-Anhydroglucitol was likely to be associated with
β
-cell function. Further analysis with large sample size and prospective study design is warranted to validate our findings. Objective. The aim of this study was to explore the association of 1,5-anhydroglucitol with acute C peptide response (ACPR) to arginine among patients with type 2 diabetes. Methods. Patients with type 2 diabetes were enrolled from the Department of Endocrinology and Metabolism, Shanghai Sixth People’s Hospital. ACPR was assessed using arginine stimulation test. Decreased β-cell function was defined as ACPR<2.1. Multivariable logistic regression models were used to demonstrate the association between 1,5-anhydroglucitol and decreased β-cell function. Results. Finally, 623 patients with type 2 diabetes were enrolled into the analysis. Multivariable-adjusted odds ratios for decreased β-cell function across quartiles of 1,5-anhydroglucitol were 1.00, 0.47 (95% confidence interval (CI) 0.23-0.99), 0.41 (95% CI 0.20-0.84), and 0.27 (95% CI 0.13-0.57) (Ptrend=0.042), respectively. When 1,5-anhydroglucitol was considered as a continuous variable after logarithm, the corresponding odds ratio was 0.40 (95% CI 0.23-0.71). Conclusions. We demonstrated a dose-response linear association between 1,5-anhydroglucitol and ACPR. 1,5-Anhydroglucitol was likely to be associated with β-cell function. Further analysis with large sample size and prospective study design is warranted to validate our findings. OBJECTIVEThe aim of this study was to explore the association of 1,5-anhydroglucitol with acute C peptide response (ACPR) to arginine among patients with type 2 diabetes. METHODSPatients with type 2 diabetes were enrolled from the Department of Endocrinology and Metabolism, Shanghai Sixth People's Hospital. ACPR was assessed using arginine stimulation test. Decreased β-cell function was defined as ACPR < 2.1. Multivariable logistic regression models were used to demonstrate the association between 1,5-anhydroglucitol and decreased β-cell function. RESULTSFinally, 623 patients with type 2 diabetes were enrolled into the analysis. Multivariable-adjusted odds ratios for decreased β-cell function across quartiles of 1,5-anhydroglucitol were 1.00, 0.47 (95% confidence interval (CI) 0.23-0.99), 0.41 (95% CI 0.20-0.84), and 0.27 (95% CI 0.13-0.57) (P trend = 0.042), respectively. When 1,5-anhydroglucitol was considered as a continuous variable after logarithm, the corresponding odds ratio was 0.40 (95% CI 0.23-0.71). CONCLUSIONSWe demonstrated a dose-response linear association between 1,5-anhydroglucitol and ACPR. 1,5-Anhydroglucitol was likely to be associated with β-cell function. Further analysis with large sample size and prospective study design is warranted to validate our findings. Objective. The aim of this study was to explore the association of 1,5-anhydroglucitol with acute C peptide response (ACPR) to arginine among patients with type 2 diabetes. Methods. Patients with type 2 diabetes were enrolled from the Department of Endocrinology and Metabolism, Shanghai Sixth People's Hospital. ACPR was assessed using arginine stimulation test. Decreased [beta]-cell function was defined as ACPR <2.1. Multivariable logistic regression models were used to demonstrate the association between 1,5-anhydroglucitol and decreased [beta]-cell function. Results. Finally, 623 patients with type 2 diabetes were enrolled into the analysis. Multivariable-adjusted odds ratios for decreased [beta]-cell function across quartiles of 1,5-anhydroglucitol were 1.00, 0.47 (95% confidence interval (CI) 0.23-0.99), 0.41 (95% CI 0.20-0.84), and 0.27 (95% CI 0.13-0.57) ([P.sub.trend] = 0.042), respectively. When 1,5-anhydroglucitol was considered as a continuous variable after logarithm, the corresponding odds ratio was 0.40 (95% CI 0.23-0.71). Conclusions. We demonstrated a dose-response linear association between 1,5-anhydroglucitol and ACPR. 1,5-Anhydroglucitol was likely to be associated with [beta]-cell function. Further analysis with large sample size and prospective study design is warranted to validate our findings. The aim of this study was to explore the association of 1,5-anhydroglucitol with acute C peptide response (ACPR) to arginine among patients with type 2 diabetes. Patients with type 2 diabetes were enrolled from the Department of Endocrinology and Metabolism, Shanghai Sixth People's Hospital. ACPR was assessed using arginine stimulation test. Decreased -cell function was defined as ACPR < 2.1. Multivariable logistic regression models were used to demonstrate the association between 1,5-anhydroglucitol and decreased -cell function. Finally, 623 patients with type 2 diabetes were enrolled into the analysis. Multivariable-adjusted odds ratios for decreased -cell function across quartiles of 1,5-anhydroglucitol were 1.00, 0.47 (95% confidence interval (CI) 0.23-0.99), 0.41 (95% CI 0.20-0.84), and 0.27 (95% CI 0.13-0.57) ( = 0.042), respectively. When 1,5-anhydroglucitol was considered as a continuous variable after logarithm, the corresponding odds ratio was 0.40 (95% CI 0.23-0.71). We demonstrated a dose-response linear association between 1,5-anhydroglucitol and ACPR. 1,5-Anhydroglucitol was likely to be associated with -cell function. Further analysis with large sample size and prospective study design is warranted to validate our findings. |
Audience | Academic |
Author | Shen, Yun Zhou, Jian Lu, Wei Ma, Xiaojing Hu, Gang Bao, Yuqian Lu, Jingyi Zhu, Wei Mo, Yifei Si, Yiming Zhang, Lei |
AuthorAffiliation | 1 Department of Endocrinology and Metabolism, Shanghai Clinical Center for Diabetes, Shanghai Diabetes Institute, Shanghai Key Laboratory of Diabetes Mellitus, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai, China 200233 2 Pennington Biomedical Research Center, Baton Rouge, Louisiana, USA 70806 |
AuthorAffiliation_xml | – name: 2 Pennington Biomedical Research Center, Baton Rouge, Louisiana, USA 70806 – name: 1 Department of Endocrinology and Metabolism, Shanghai Clinical Center for Diabetes, Shanghai Diabetes Institute, Shanghai Key Laboratory of Diabetes Mellitus, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai, China 200233 |
Author_xml | – sequence: 1 fullname: Hu, Gang – sequence: 2 fullname: Zhou, Jian – sequence: 3 fullname: Bao, Yuqian – sequence: 4 fullname: Lu, Wei – sequence: 5 fullname: Mo, Yifei – sequence: 6 fullname: Zhang, Lei – sequence: 7 fullname: Ma, Xiaojing – sequence: 8 fullname: Lu, Jingyi – sequence: 9 fullname: Si, Yiming – sequence: 10 fullname: Shen, Yun – sequence: 11 fullname: Zhu, Wei |
BackLink | https://www.ncbi.nlm.nih.gov/pubmed/32775460$$D View this record in MEDLINE/PubMed |
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CitedBy_id | crossref_primary_10_1210_clinem_dgab581 crossref_primary_10_1136_bmjdrc_2020_001869 crossref_primary_10_3389_fendo_2022_1037289 crossref_primary_10_3389_fendo_2023_1144834 crossref_primary_10_3389_fendo_2024_1383483 |
Cites_doi | 10.1007/s12020-012-9760-6 10.2337/diabetes.54.7.2126 10.1016/j.diabres.2019.107904 10.1016/j.bbrc.2011.12.113 10.1152/ajpendo.1992.263.2.E268 10.2337/dc06-1910 10.1007/s11695-016-2455-y 10.1016/j.molmet.2017.06.019 10.1016/j.cmet.2018.09.008 10.1001/jama.2017.7596 10.1016/j.diabres.2009.01.002 10.1089/dia.2014.0346 10.2337/diabetes.52.1.102 10.2337/diab.26.7.605 10.1111/j.1432-1033.1996.0832r.x 10.1016/j.cell.2012.02.010 10.1172/JCI111542 10.1007/s12020-020-02201-y 10.2337/diabetes.53.suppl_3.S16 10.1093/oxfordjournals.jbchem.a122590 10.1007/BF00279131 10.2337/db19-0131 10.1210/jendso/bvz023 10.1016/0304-4165(96)00050-5 10.1210/jc.2004-1133 10.1111/dme.12859 10.2337/db13-0152 10.1007/s00592-019-01452-0 10.1038/nature05482 10.1016/j.regpep.2004.06.004 |
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Copyright | Copyright © 2020 Yun Shen et al. COPYRIGHT 2020 Hindawi Limited Copyright © 2020 Yun Shen et al. This work is licensed under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. Copyright © 2020 Yun Shen et al. 2020 |
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Snippet | Objective. The aim of this study was to explore the association of 1,5-anhydroglucitol with acute C peptide response (ACPR) to arginine among patients with... The aim of this study was to explore the association of 1,5-anhydroglucitol with acute C peptide response (ACPR) to arginine among patients with type 2... Objective . The aim of this study was to explore the association of 1,5-anhydroglucitol with acute C peptide response (ACPR) to arginine among patients with... OBJECTIVEThe aim of this study was to explore the association of 1,5-anhydroglucitol with acute C peptide response (ACPR) to arginine among patients with type... |
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SubjectTerms | Adult Age Analysis Arginine Arginine - pharmacology Biomarkers - analysis Biomarkers - blood Blood Glucose - metabolism C-Peptide - analysis C-Peptide - blood Cholesterol Deoxyglucose - analysis Deoxyglucose - blood Diabetes Diabetes Mellitus, Type 2 - blood Diabetes Mellitus, Type 2 - diagnosis Diabetes Mellitus, Type 2 - physiopathology Diet Female Glucose Glycated Hemoglobin A - metabolism Hemoglobin Humans Hyperglycemia Insulin resistance Insulin-Secreting Cells - physiology Male Metabolism Middle Aged Pancreatic Function Tests - methods Peptides Physiological aspects Predictive Value of Tests Regression analysis Type 2 diabetes Variables |
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Title | Association between 1,5-Anhydroglucitol and Acute C Peptide Response to Arginine among Patients with Type 2 Diabetes |
URI | https://search.emarefa.net/detail/BIM-1183126 https://dx.doi.org/10.1155/2020/4243053 https://www.ncbi.nlm.nih.gov/pubmed/32775460 https://www.proquest.com/docview/2429646731/abstract/ https://search.proquest.com/docview/2432868188 https://pubmed.ncbi.nlm.nih.gov/PMC7391082 https://doaj.org/article/72dc1288afa24e4e86cf11bdd6a94657 |
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