Association between 1,5-Anhydroglucitol and Acute C Peptide Response to Arginine among Patients with Type 2 Diabetes

• Published in: Journal of Diabetes Research Vol. 2020; no. 2020; pp. 1 - 7
• Main Authors: Hu, Gang, Zhou, Jian, Bao, Yuqian, Lu, Wei, Mo, Yifei, Zhang, Lei, Ma, Xiaojing, Lu, Jingyi, Si, Yiming, Shen, Yun, Zhu, Wei
• Format: Journal Article
• Language: English
• Published: Cairo, Egypt Hindawi Publishing Corporation 2020; Hindawi; Hindawi Limited; Wiley
• Subjects: Adult; Age; Analysis; Arginine; Arginine - pharmacology; Biomarkers - analysis; Biomarkers - blood; Blood Glucose - metabolism; C-Peptide - analysis; C-Peptide - blood; Cholesterol; Deoxyglucose - analysis; Deoxyglucose - blood; Diabetes; Diabetes Mellitus, Type 2 - blood; Diabetes Mellitus, Type 2 - diagnosis; Diabetes Mellitus, Type 2 - physiopathology; Diet; Female; Glucose; Glycated Hemoglobin A - metabolism; Hemoglobin; Humans; Hyperglycemia; Insulin resistance; Insulin-Secreting Cells - physiology; Male; Metabolism; Middle Aged; Pancreatic Function Tests - methods; Peptides; Physiological aspects; Predictive Value of Tests; Regression analysis; Type 2 diabetes; Variables; China; United States > US
• ISSN: 2314-6745; 2314-6753
• DOI: 10.1155/2020/4243053

Objective. The aim of this study was to explore the association of 1,5-anhydroglucitol with acute C peptide response (ACPR) to arginine among patients with type 2 diabetes. Methods. Patients with type 2 diabetes were enrolled from the Department of Endocrinology and Metabolism, Shanghai Sixth People’s Hospital. ACPR was assessed using arginine stimulation test. Decreased β-cell function was defined as ACPR<2.1. Multivariable logistic regression models were used to demonstrate the association between 1,5-anhydroglucitol and decreased β-cell function. Results. Finally, 623 patients with type 2 diabetes were enrolled into the analysis. Multivariable-adjusted odds ratios for decreased β-cell function across quartiles of 1,5-anhydroglucitol were 1.00, 0.47 (95% confidence interval (CI) 0.23-0.99), 0.41 (95% CI 0.20-0.84), and 0.27 (95% CI 0.13-0.57) (Ptrend=0.042), respectively. When 1,5-anhydroglucitol was considered as a continuous variable after logarithm, the corresponding odds ratio was 0.40 (95% CI 0.23-0.71). Conclusions. We demonstrated a dose-response linear association between 1,5-anhydroglucitol and ACPR. 1,5-Anhydroglucitol was likely to be associated with β-cell function. Further analysis with large sample size and prospective study design is warranted to validate our findings.